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phosphatase |
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phosphatase [′fäs·fə‚tās] (biochemistry) An enzyme that catalyzes the hydrolysis and synthesis of phosphoric acid esters and the transfer of phosphate groups from phosphoric acid to other compounds. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| PPMD1, a member of the PP2C family of Ser/Thr protein phosphatases that is induced in a p53-dependent manner in response to various environmental stresses, reduces the phosphorylation of p53 through negative regulation of p38 MAP kinase, and in turn suppresses p53-mediated transcription and apoptosis (Bulavin et al. These gene families, which include G protein-coupled receptors, ion channels, kinases, nuclear receptors, phosphatases, phosphodiesterases, transporters, and proteases, contain the genes of greatest interest to the pharmaceutical industry as new drug targets. [40-42] Amifostine is a prodrug that is metabolized into its active form by desphosphorylation of the compound by membrane-bound alkaline phosphatases. |
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