Adjunctive photodynamic therapy (PDT or aPDT) is a low-power laser (diode laser, 660 to 810 nm) used in combination with a photosensitizing agent
for antimicrobial purposes in the nonsurgical treatment of periodontitis.
PDT is performed by first administering to the patient a photosensitizing agent
, which is usually given intravenously but can also be given orally or applied topically.
An important step has been the discovery in his laboratory that low-level blue light, shined on the skin during incubation with the photosensitizing agent
, appears to inhibit porphyrin synthesis selectively in the epidermis.
Topical or systemic photosensitizing agents
include drugs (e.
However, cold-pressed lime oil contains compounds that can act as photosensitizing agents
which can cause accelerated burning and skin damage due to the skin's increased sensitivity to UV light.
In our initial work, the photophysical and photochemical characteristics of the photosensitizing agents
protoporphyrin IX (PpIX) and Verteporfin were investigated as a function of TPE (3, 4).