Transient photosensitivity is the most hindering complication, although newer photosensitizing agents
are shortening its duration.
Special care should be exercised in treating patients who are receiving concomitant therapy (either topically or systemically) with known photosensitizing agents
Diagnostic applications of "phototesting" utilize local light applications that assist in detecting photosensitizing agents
However, cold-pressed lime oil contains compounds that can act as photosensitizing agents
which can cause accelerated burning and skin damage due to the skin's increased sensitivity to UV light.
In our initial work, the photophysical and photochemical characteristics of the photosensitizing agents
protoporphyrin IX (PpIX) and Verteporfin were investigated as a function of TPE (3, 4).