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platelet-activating factor

   Also found in: Wikipedia 0.01 sec.
platelet-activating factor [¦plāt·lət ′ak·tə‚vād·iŋ ‚fak·tər]
(immunology)
A phospholipid released by leukocytes that causes aggregation of platelets and other effects, such as an increase in vascular permeability and bronchoconstriction. Abbreviated PAF.


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This results in the release of cytokines with vasoactive and procoagulant properties (interleukins, tumor necrosis factor, platelet-activating factor, and urokinase) (17,18).
These cytokines include platelet-derived growth factor, transforming growth factor B1, platelet-derived epidermal growth factor, platelet-derived angiogenesis factor platelet factor 4, and platelet-activating factor.
Folts suggests that alprazolam acts by blocking platelet-activating factor, a clot-inducing protein produced by cells lining the blood vessels.
 
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