Polymyxins

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Polymyxins

a group of polypeptide antibiotics, or acylcy-clopeptides, produced by certain strains of bacilli, primarily Bacillus polymyxa. The molecules of most polymyxins contain residues of threonine, lucine, α,γ-diaminobutyric acid, and 6-methyloctanoic acid.

Polymyxins are active only against gram-negative bacteria such as Pseudomonas aeruginosa, dysentery causative agent, Escherichia coli, Salmonellae, and Klebsiellae. The antimicrobial mechanism in polymyxins is associated with damage to the membrane of the bacterial cell. Polymyxins are differentiated by their nature and by the intensity of their side effects, which are chiefly neurotoxic and nephrotoxic and which restrict their use. Polymyxins B, M, and E (colistin) are used in medical practice.

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No references found			The few therapeutic options for treating infections caused by organisms containing these [beta]-lactamases are aminoglycosides, glycylcyclines, polymyxins, or combinations (1). Klebsiella pneumoniae Carbapenemase, Canada by Pillai, Dylan R.; Melano, Roberto; Rawte, Prasad; Lo, Stephen; Tijet, Nathalie; Fuksa, Milan; Roda, / Emerging Infectious Diseases Other antibiotic groups -- polymyxins and minocyclines -- have been shown to be more effective. Acinetobacter is emerging hospital superbug: study by AFP / AFP Global Edition Baird-Parker medium supplemented with acriflavine, polymyxins and sulphonamide for the selective isolation of Staphylococcus aureus from heavily contaminated materials. Methicillin-resistant Staphylococcus aureus in poultry by Persoons, Davy; Van Hoorebeke, Sebastiaan; Hermans, Katleen; Butaye, Patrick; de Kruif, Aart; Haeseb / Emerging Infectious Diseases			polymetamorphism Polymethine Dyes polymethyl methacrylate Polymethyl Methacrylate PMMA Polymetry Polymia polymictic polymignite polymignyte polymodal distribution Polymodality polymolecular assembly polymorph polymorphic polymorphic lambda-calculus polymorphic modification polymorphic system polymorphic virus Polymorphism polymorphonuclear leukocyte Polymorphosis polymorphous polymyarian polymyositis polymyxin Polymyxins polyn'ya Polynemidae Polynesia Polynesian Polynesian Languages Polynesian Subregion Polynesians Polyneuritis Polynices Polynoidae Polynok Polynomial polynomial equation polynomial function polynomial time polynomial trend polynomial-time polynomial-time algorithm Polynosic Fiber Polynov, Boris Polynov, Boris Borisovich polynuclear hydrocarbon polynucleotide Polynya Polyodontidae			Polymox polymyalgia Polymyalgia rheumatica Polymyalgia rheumatica Polymyalgia Rheumatica and/or Giant Cell Arteritis Polymyalgia Rheumatica with Giant Cell Arteritis polymyarian polymyarian polymyoclonus Polymyodae Polymyodous Polymyoid polymyopathy polymyositis polymyositis polymyositis polymyositis Polymyositis-dermatomyositis polymyositis/dermatomyositis polymyxin polymyxin polymyxin Polymyxin B Polymyxin B Polymyxin B Polymyxin b sulfate polymyxin B sulphate Polymyxin E Polymyxin E Polymyxin E Polymyxins polyn'ya Polyneices Polyneices Polyneikes Polyneikes Polyneme Polynemid Polynemid Polynemidae Polynemidae Polynemoid Polynesia Polynesia Polynesian Polynesian Polynesian Polynesian Cultural Center Polynesian islands Polynesian islands Polynesian language Polynesian languages Polynesian Limited Samoa Polynesian Lithosphere and Upper Mantle Experiment Polynesian Subregion Polynesian tattler Polynesian Voyaging Society Polynesians Polynesians polynesic Polynesie

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