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see peptidepeptide,
organic compound composed of amino acids linked together chemically by peptide bonds. The peptide bond always involves a single covalent link between the α-carboxyl (oxygen-bearing carbon) of one amino acid and the amino nitrogen of a second amino acid.
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an organic compound containing six to 80–90 amino acid residues; the upper limit corresponds to a molecular weight of about 10,000. Such polypeptides, unlike proteins, can pass through semipermeable membranes.

The simple polypeptides are crystalline substances that are readily soluble in water and have chemical properties similar to those of amino acids. The complex polypeptides are amorphous and react with water to yield colloidal solutions. Polypeptides are formed in the organism during enzymatic proteolysis (autolysis of tissue, digestion, and so on) and during biosynthesis from amino acids. Many natural polypeptides exhibit the biological activity of hormones, antibiotics, and toxins. Synthetic polypeptides serve as models in studying the structure and biological activity of proteins.


A chain of amino acids linked together by peptide bonds but with a lower molecular weight than a protein; obtained by synthesis, or by partial hydrolysis of protein.
References in periodicals archive ?
Mechanical & cell culture properties of elastin-like polypeptide, collagen, bioglass, and carbon nanosphere composites.
The licensed technology is directed to specially designed nanoparticles that carry and deliver therapeutic bioactive proteins, polypeptides and peptides to targeted cells, such as cancer cells.
Chemosynthetic polypeptide drugs are drugs combining the certain amino acids in chemical methods, which are characterized by favorable curable effects, few side-effects, high specificities and other advantages.
Although the degree of sequence diversity between subtypes is great, particularly in the HA1 polypeptides (34%-59% homology between subtypes), more conserved regions are found in HA2 (51%-80% homology between subtypes).
This new patent covers polypeptides of mitogen-activated protein kinase kinases (MKKs) that are involved in the c-Jun N-terminal kinase (JNK) pathways.
Two of the genes encode acidic, glycine-rich polypeptides, says Lalita Ramakrishnan of the Stanford University School of Medicine.
According to historical data, the approval ratio of polypeptide drugs in clinical research is 23 % to 26 %.
and have the ability to fragment polypeptides (MS / MS) with a speed
These proteins and polypeptides were discovered through our own datamining capability and were synthesized chemically in multimilligram quantities in high purity," said Keith Rose, GeneProt's CSO.
The most abundant polypeptides in Btk BT products were those corresponding to pro-[Delta]-endotoxin (132-134 kDa) and activated-[Delta]-endotoxin (60-67 kDa) pools.
penetrans polypeptides from whole-cell lysates both from the type strain GTU-54-6A1 and from our isolate HF-1 were done as previously described (10).