posttranslational modification

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posttranslational modification

[‚pōs·tranz¦lā·shən·əl ‚mäd·ə·fə′kā·shən]
(cell and molecular biology)
Any polypeptide alteration that occurs after synthesis of the chain.
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We also identified receptors involved in the perception of these peptide hormones and two important transferases required for post-translational modification of the hormones.
The 16 chapters describe methods for network inference and modeling using transcriptional data, the role of post-translational modification in information processing, the generation of metabolomic networks, recent advances in cancer network medicine, and lessons learned from phenotyping.
Vitamin K-dependent proteins (VKDPs), which require post-translational modification to achieve biological activity, seem to contribute to thrombus formation, vascular calcification, and vessel stiffness.
Their topics include analyzing and predicting protein post-translational modification sites, algorithm frameworks for determining the connectivity of protein disulfide, discovering three dimensional protein structures for optimal structure alignment, identifying protein complexes from protein-protein interaction networks, and using support vector machines to compare protein-related drug activity.
Proteomics service provider Applied Biomics Inc on Tuesday announced the addition of the Global Protein Post-Translational Modification (PTM) Profiling service to its proteomics line.
O-GlcNAc cycling: How a single sugar post-translational modification is changing the way we think about signaling networks.
Scientists who use the techniques--and in many cases helped devise them--explain methods for transcriptional factor trafficking and post-translational modification, the cytoplasmic-nuclear trafficking of transcription factors, post-translational modification and impact on function, and protocols for optimizing functional assays.
Post-translational modification of RBPs generates additional layers of complexity, as it can modify the RNA binding, function and localisation of the RNP.
Acetylation is one of the most important post-translational modification of proteins determining the structure, function and intracellular localization that plays an important role in the signal transduction pathways related to diverse cell functions, both during unstimulated and stress conditions.
This raft association suggested the possible post-translational modification of DATs with lipids, a characteristic common to many raft associated proteins.
The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity.
A particularly challenging area of study within proteomics is post-translational modification of proteins.

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