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posttranslational modification |
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posttranslational modification [‚pōs·tranz¦lā·shən·əl ‚mäd·ə·fə′kā·shən] (cell and molecular biology) Any polypeptide alteration that occurs after synthesis of the chain. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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To fulfill this demand, more advanced studies will be needed, taking advantage of the biophysics and understanding of posttranslational modifications that mandate protein folding and the ultimate form of the three-dimensional structures. However, 2-D gels provide a visual reference of protein expression for comparison, while also permitting the experimenter to observe posttranslational modifications and protein cleavage events, which would not be evident by using MUDPIT. These tools are applied to the solution of biological problems that involve, for example, the rapid identification of proteins, the elucidation of posttranslational modifications and the definition of sites of functional interaction between biomolecules. |
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