pregnenolone


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pregnenolone

[preg′nen·ə‚lōn]
(biochemistry)
C21H32O2 A steroid ketone that is formed as an oxidation product of cholesterol, stigmasterol, and certain other steroids.
References in periodicals archive ?
Recent tests show that people with Alzheimer's disease given oral doses of pregnenolone, which the body converts to pregnenolone sulfate, experience no memory improvement, says Roberts.
P450scc converts cholesterol into pregnenolone, which is ultimately transferred to smooth endoplasmic reticulum, where the synthesis of testosterone takes place via the actions of 3[beta]-hydroxysteroid dehydrogenase (3[beta]-HSD), I7[alpha]-hydroxy/ [C.
Longitudinal study of plasma pregnenolone and 17-hydroxypregnenolone in full-term and preterm neonates at birth and during the early neonatal period.
Pregnenolone also is produced by the adrenal glands and is important in regulating the adaptive homeostat.
Only three major enzyme reactions may be needed for the conversion of pregnenolone or progesterone to the simplest steroid with CG activity.
It is made with ginkgo biloba, pregnenolone and phosphatidyl serine.
Once in the mitochondria of adrenal and gonadal cells, cholesterol can be converted by enzymes into a "pre-hormone," pregnenolone, that in turn is converted by additional cellular enzymes into a whole range of steroid hormones.
estradiol, progesterone, pregnenolone, thyroid) and chelation to remove heavy metals are also used as needed.
For example, increased OLF was reported in animals and/or culture models using ACTH (39,40); angiotensin II (41); combinations of ACTH, angiotensin II, aldosterone, and cortisol (42, 43); and progesterone and pregnenolone (44).
and/or adrenal shots of cortisol, DHEA, and pregnenolone with methyl B12 and folic acid (see my previous columns).
Adult mate rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017[alpha] and P450 aromatase localized in neurons.