The combined oral contraceptive pills containing third- (and fourth-) generation progestins
They combined a transdermal (skin) gel containing the male hormone testosterone and a gel containing a new synthetic progestin
For example, the Yasmin label now includes the statement that based on the currently available information, "DRSP [drospirenone]-containing COCs may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing the progestin
levonorgestrel or some other progestins
The team, led by the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) in Vienna, in collaboration with scientists based at institutions including University College London, demonstrated that progestin
can also trigger the rankl protein in breast cells in mice.
These are mostly low-grade adenocarcinomas with a good prognosis and well-described risk factors such as nulliparity, obesity, hyperoestrogenism, other cancers, tamoxifen use and inadequate progestin
cover when taking oestrogens.
They found that they had a significantly higher risk for getting breast cancer if they used progestins
, and a reduced risk if they used natural progesterone--either alone or with estrogens.
are also used alone for birth control, and for treatment of a variety of other conditions, including abnormal uterine bleeding and amenorrhea (absence of periods); endometriosis; breast, kidney or uterine cancer; and loss of appetite and weight related to AIDS and cancer.
It is important to note that estrogen therapy, with or without a progestin
, should not be used for the prevention of coronary heart disease," concludes Dr.
The first such product to contain drospirenone, a synthetic progestin
and spironolactone analog with antimineralocorticoid activity.
The increased risk of stroke in the estrogen-alone study is similar to what was found in the WHI study of estrogen plus progestin
when that trial was stopped in July 2002.
Here's the reality behind the WHI: Basically, in 2002 the WHI found that women taking the hormone therapy Prempro, composed of progestin
(a synthetic progestogen known as medroxyprogesterone acetate or MPA) and conjugated equine estrogen, had a 26 percent increased risk of invasive breast cancer, a 29 percent increased risk of heart attack, a 41 percent higher rate of stroke and more than a 100 percent increase in blood clots in the lung.
Sitruk-Ware recently outlined the properties of various progestins
and progesterone, paying particular attention to potential risks and benefits.