Propiolactone


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Propiolactone

 

(β-propiolactone), an internal cyclic ether of β-hydroxypropionic acid with the structure

Propiolactone is a colorless liquid with a pungent odor, a melting point of –33.4°C, a boiling point of 155°C, and a density of 1.146 g/cm3 (20°C). It is obtained by catalytic interaction of formaldehyde (CH2O) with ketene (CH2=C=O). Solutions and vapors of propiolactone have strong bactericidal effects. Propiolactone is used in medicine for sterilizing blood, vaccines, enzymes, and other biological preparations; it is also used as a fumigant.

References in periodicals archive ?
The 3rd passage of IBH-HPS virus was taken and inactivated by adding beta- propiolactone (Fellows Medical, Mich).
Propiolactone is logically expected to be a human carcinogen since it has shown to cause skin and stomach cancers in animals.
In addition, the partners will determine the optimum route to acrylic acid, which can be produced via the ring-opening of propiolactone, which is in turn obtained directly from the reaction of E0 and CO, or the propiolactone can be polymerized to polypropiolactone (PPL).