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protease inhibitor

   Also found in: Dictionary/thesaurus, Medical, Legal, Acronyms, Wikipedia 0.01 sec.
protease inhibitor (prō`tē-ās'), any of a class of drugs that interfere with replication of the AIDS AIDS or acquired immunodeficiency syndrome, fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders.
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 virus (HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States.
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), by blocking an enzyme (protease) necessary in the late stages of its reproduction. Clinical trials of the protease inhibitor indinavir have shown it to be especially beneficial in combination with the anti-HIV drugs AZT AZT or zidovudine , drug used to treat patients infected with the human immunodeficiency virus (HIV), which causes AIDS; also called azidothymidine. Originally developed in 1964 as an anticancer drug, AZT was never approved for that purpose.
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 and 3TC, which act by blocking a different enzyme, reverse transcriptase. Saquinavir, the first member of the class to be marketed, was approved for use in 1995 by the Food and Drug Administration.


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The team then used a specific small-molecule protease inhibitor of calpain in these mice.
95 Hardcover QP551 Lundblad brings together solution protein chemistry and proteomic technology to describe the chemical modification of proteins, the application of site-specific chemical modification to proteomics, protease inhibitors in sample preparation, and prefractionation.
The anti-HIV drug "cocktail" had begun changing the face of the AIDS epidemic a year after the introduction of protease inhibitors, The Advocate reported in late 1996.
 
 
 
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