proteasome


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proteasome

[′prōd·ē·ə‚sōm]
(biochemistry)
A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site for degradation of most intracellular proteins.
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In general, inhibition of NF-kB translocation and proteasome activity was considered to inhibit cell proliferation.
CA responses were subtracted from DE or SOA responses, and mixed linear models with F-tests were used to test the effect of exposure to each aerosol on WBC and RBC proteasome activity.
Triphase Accelerator is developing marizomib in both intravenous and oral formulations as a proteasome inhibitor for hematologic malignancies and solid tumors.
Conclusions: The upregulation of the proteasome activity observed upon quercetin or rutin treatment could be afforded by a mild increased of PARP-1.
Cilcane is a pentapeptide drug with an excellent safety profile and a novel mechanism of action compared to existing myeloma treatments, Research suggests the product will be synergistic in combination with a proteasome inhibitor, a class of drug normally given as a front line treatment for this disease and that this approach can also be extended to the treatment of other cancers, including breast cancer.
Proteasome inhibition reduces avian reovirus replication and apoptosis induction in cultured cells.
A number of studies suggest that oxidative stress can target the proteasome and impair its ability to correctly degrade oxidized proteins (reviewed in [6]).
These projects are in early stage of development, but build on Takeda's work with proteasome inhibitors, which has already led to new medicines for other diseases, including certain types of cancer," said Dr Timothy Wells, chief scientific officer at Medicines for Malaria Venture (MMV).
Since the chemical structure of terazosin is also a C-terminal furan-contained structure [16], which is considered to be one of classic structures of potential 20S proteasome inhibitors.
Botezomib is a novel proteasome inhibitor which acts by inducing bcl-2 phosphorylation and cleavage, resulting in G2M cell cycle phase arrest and apoptosis (5).
5) The marked proteins are subsequently directed to a multi-protein structure known as the proteasome, which contains enzymes that degrade and recycle the unwanted proteins.
The initiation of this front line myeloma trial represents another first in the development of MLN9708, an oral proteasome inhibitor, and is a major achievement in advancing the Takeda Oncology pipeline,' said Karen Ferrante, M.

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