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proteasome |
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proteasome [′prōd·ē·ə‚sōm] (biochemistry) A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site for degradation of most intracellular proteins. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Interestingly, the enzymes for lipid metabolism such as lipoprotein lipase (Lpl, 33-fold), cytosolic acyl-CoA thioesterase (Ctel, 5-fold), and proteasome 26S subunit ATPase-3 (Pmsc3, 4-fold) were increased. Then, they identified an elimination mechanism in which proteasome, a protease complex, degrades and eliminates abnormal proteins. Last year, the Food and Drug Administration approved the proteasome inhibitor bortezomib (Velcade) for the treatment of multiple myeloma, a cancer of the blood. |
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