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proteasome |
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proteasome [′prōd·ē·ə‚sōm] (biochemistry) A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site for degradation of most intracellular proteins. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Faustman and her colleagues have found that, in an inbred strain of mice prone to diabetes, defects in a cellular structure called the proteosome can prevent female cells from chopping up proteins as required for antigen presentation. Combination studies with GX15-070 demonstrated that it enhanced the anti-myeloma activity stimulated by melphalan, dexamethasone, and bortezomib, a proteosome inhibitor. The phosphorylated PTEN (p-PTEN) is less susceptible to degradation by the proteosome but is less active. |
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