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protonation

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protonation (prō`tənā'shən), in chemistry, addition of a proton proton, elementary particle having a single positive electrical charge and constituting the nucleus of the ordinary hydrogen atom. The positive charge of the nucleus of any atom is due to its protons.
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 to an atom, molecule, or ion. The proton is the nucleus of the hydrogen hydrogen (hī`drəjən) [Gr.,=water forming], gaseous chemical element; symbol H; at. no. 1; at. wt. 1.00794; m.p. −259.
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 atom; the positive hydrogen ion, H+, consists of a single proton. An example of protonation is the formation of the ammonium group ammonium group, in chemistry, a positively charged nitrogen atom joined by single bonds to four other atoms or groups. The simplest ammonium group, NH4+, is formed by protonation of ammonia , NH3, e.g.
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 NH4+ from ammonia, NH3. Protonation often occurs in the reaction of an acid with a base to form a salt (see acids and bases acids and bases, two related classes of chemicals; the members of each class have a number of common properties when dissolved in a solvent, usually water.

Properties


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; salts salt, chemical compound (other than water) formed by a chemical reaction between an acid and a base (see acids and bases ).

Characteristics and Classification of Salts


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). Protonation differs from hydrogenation hydrogenation (hīdrôj`ənā'shən, hī'drəjənā`shən)
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 in that during protonation a change in charge of the protonated species occurs, whereas the charge is unaffected during hydrogenation.


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b], will be different in PBS if the protonation equilibrium is different on the bead surface from that in solution.
This prevented structural differences caused by different protonation states, which might lead to differences in the calculation of the molecular descriptors.
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.
 
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