oncogene

(redirected from Protooncogene)
Also found in: Dictionary, Thesaurus, Medical.

oncogene

any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer

oncogene

[′äŋ·kō‚jēn]
(genetics)
A gene whose mutation can lead to cancer in experimental animals and humans.
References in periodicals archive ?
Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.
Specific mutations of the RET protooncogene are related to disease phenotype in MEN 2A and FMTC.
Expression of the protooncogene eIF4E in inflammation of the oral cavity.
Studies of the HER-2/neu protooncogene in human breast and ovarian cancer.
The protooncogene c-Myc is an essential regulator of neural crest formation in Xenopus.
2001), interphotoreceptor retinoid binding protein (IRBP) gene (Jansa and Weksler 2003), growth hormone receptor (GHR), breast cancer gene 1 (BRCA1), recombination activating gene 1 (RAG1), and protooncogene c-myc (Steppan et al.
The translation initiation factor-1 [delta] subunit, a Cd-responsive protooncogene with oncogenic potential (Joseph et al.
Phase II pilot study of herceptin combined with taxotere and carboplatin (TCH) in metastatic breast cancer (MBC) patients overexpressing the HER2-neu protooncogene.
Common to all Burkitt lymphomas, endemic or sporadic, are distinctive chromosomal translocations that reactivate expression of the c-myc protooncogene and comprise the primary oncogenic mechanism.
A major focus of targeted therapies has been the protooncogene for Bcl-2, which is linked to chemoresistance, a problem in melanoma patients.
chromosome X, and a method of diagnosing rheumatoid arthritis, which is a mutant of protooncogene Dbl