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oncogene |
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oncogeneGene that can cause cancer. It is a sequence of DNA that has been altered or mutated from its original form, the proto-oncogene (see mutation). Proto-oncogenes promote the specialization and division of normal cells. A change in their genetic sequence can result in uncontrolled cell growth, ultimately causing the formation of a cancerous tumour. In humans, proto-oncogenes can be transformed into oncogenes in three ways: point mutation (alteration of a single nucleotide base pair), translocation (in which a segment of the chromosome breaks off and attaches to another chromosome), or amplification (increase in the number of copies of the proto-oncogene). Oncogenes were first discovered in certain retroviruses and were later identified as cancer-causing agents in many animals. See also J. Michael Bishop; Harold Varmus. oncogene any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer oncogene [′äŋ·kō‚jēn] (genetics) A gene whose mutation can lead to cancer in experimental animals and humans. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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No references found | 1 CpG island methylator phenotype (CIMP) is a subset of colorectal carcinoma (CRC) characterized by concordant hypermethylation of multiple promoter CpG island loci2 and peculiar clinicopathologic findings, such as close association with microsatellite instability (MSI), proximal tumor location, female preponderance, high frequency of mutation of the protooncogene BRAF, and low frequency of mutation of the proto- oncogene KRAS. 2001), interphotoreceptor retinoid binding protein (IRBP) gene (Jansa and Weksler 2003), growth hormone receptor (GHR), breast cancer gene 1 (BRCA1), recombination activating gene 1 (RAG1), and protooncogene c-myc (Steppan et al. The translation initiation factor-1 [delta] subunit, a Cd-responsive protooncogene with oncogenic potential (Joseph et al. |
Protooncogene |
protonemal protonemata protonemata protonematal protonematal Protonephridia Protonephridia Protonephridia Protonephridium Protonephridium Protonephridium protoneuron protonic protonic protonic protonic acid Protonium Protonix Protonix IV Protonorse Protonotaria Protonotaria citrea protonotaries protonotary protonotary Protons Protons Protons Protons Electrons Always Cause Explosions PROTOOL Protooncogene ProtoorganismProtopam Chloride Protopapas protopathic protopathic Protopathic Pain protopathic sensibility protopathic sensibility protopathic sensibility protopathic sensibility protopathic sensitivity protopathy protopathy protopepsia Protophane protophilic protophilic protophloem protophloem Protophormia terraenovae protophyrinogen oxidase Protophyta Protophyta Protophyte Protophytology Protopic Protopine Protoplanet Protoplanet Protoplanet theory | |||||||
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