oncogene

(redirected from Protooncogene)
Also found in: Dictionary, Thesaurus, Medical.

oncogene

any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer

oncogene

[′äŋ·kō‚jēn]
(genetics)
A gene whose mutation can lead to cancer in experimental animals and humans.
References in periodicals archive ?
Co-expression of the protooncogene FOS (cfos) and an embryonic interferon (ovine trophoblastin) by sheep conceptuses during implantation.
Cell motility is controlled by 5F2/ASF through alternative splicing of the Ron protooncogene.
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.
The best characterized tumorigenic molecular changes in FTC are activating point mutations in genes of the protooncogene family comprising HRAS [5] (v-Ha-ras Harvey rat sarcoma viral oncogene homolog), KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and NRAS [neuroblastoma RAS viral (v-ras) oncogene homolog] and in the PAX8/PPARG (paired box 8/peroxisome proliferator-activated receptor gamma) fusion oncogene rearrangement (3); however, RAS gene mutations (a) occur only in 10%-25% of FTC cases, (b) are also seen in papillary thyroid carcinoma, and (c) occur equally often in FA and FTC (3-5).
Slamon DJ, Godolphin W, Jones LA, et al: Studies of the HER-2/neu protooncogene in human breast and ovarian cancer.
Mutation scanning of the RET protooncogene using high-resolution melting analysis.
Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in pre-malignant and malignant lesions of the human uterine endometrium.
Differential hypomethylation of the c-myc protooncogene in bladder cancers at different stages and grades.
The noncontinuous probes with omission of 1-3 nt of the template sequence were designed to mask nontargeted sequence variants such as benign polymorphic sites in RET protooncogene and the fibroblast growth factor receptor 3 gene (FGFR3) [5] (3).
Transcriptional activation of c-fos protooncogene by 16[beta]-estradiol: mechanism of aryl-hydrocarbon receptor-mediated inhibition.
Structural analysis of alpha-enolase: mapping the functional domains involved in down-regulation of the c-myc protooncogene.