Therefore, it is very important to guarantee adequate seric concentrations of vitamin D and the substrate for 1,25(OH)2D to all patients with CKD, which have an important loss of proximal convoluted tubule
cells due to their loss of nephron.
The opening of the proximal convoluted tubule
In managing diabetes SGLT2 inhibitors act by a novel insulin-independent mechanism by blocking glucose reabsorption in the proximal convoluted tubules
resulting in markedly increased glycosuria a mechanism not limited by the degree of insulin resistance or beta-cell dysfunction.
We developed a new algorithm to calculate the fractal dimension of convoluted objects, like the outline images of a serially sectioned proximal convoluted tubule
Analysis of volume, area and perimeter of cell nuclei in distal and proximal convoluted tubules
and also the collecting duct of the kidney in rat fetuses treated with sodium cyclamate showed that there is significant difference in the dimensions for the treated group compared to the controls.
Effect of alphatocopherol on diameter of proximal convoluted tubules
of kidney in diabetic mice.
The present study showed scattered groups of proximal convoluted tubules
with granular cytoplasm and with swollen granular cytoplasm in Larus argentatus (Figure 8).
This showed that toxic dose of acetaminophen was responsible for tubular damage especially in proximal convoluted tubules
after 48 hours.
CP is a widely used antineoplastic agent, but associated with nephrotoxicity, and prone to result in long-term renal fibrosis after administration, the damages involve both glomeruli and tubules, while the major damage happens in proximal convoluted tubules
Relatively weak cytoplasmic staining of PAX2 in the podocytes of glomeruli and epithelial cells of proximal convoluted tubules
is also detected (Figure 4, b).
The kidney section showed severe degeneration and necrosis of lining epithelium of its proximal convoluted tubules
, while spleen section showed severe congestion of red pulp and a variable degree of lymphocytes depletion from white pulp follicles.
Results and Conclusions: Main morphological changes were seen in proximal convoluted tubules
and glomeruli (HandE PAS).