It also addresses an additional issue unique to PMS2--the PMS2CL (PMS2 C-terminal like pseudogene
Published in the latest issue of the journal Nature Structural & Molecular Biology, the team's findings suggest a much larger role for pseudogenes
than previously thought -- a discovery that changes our understanding of the internal landscape of living cells, adding a new layer of complexity to an already crowded topography marked by multiple, overlapping, interacting gene networks.
Special attention was paid to the exclusion of pseudogene
influenzae and proposed as a candidate NTHI vaccine antigen, is present as a pseudogene
in F3031 and F3047, as previously reported by Kilian et al.
1541) resequenced 54 genomic DNA fragments (43,675 bases) spanning four genes (CYP3A4, CYP3A5, CYP3A7, and CYP3A43), two pseudogenes
(CYP3AP1 and CYP3AP2), and randomly selected inter-genic regions in samples from 24 Africans, 24 Caucasians, and 29 Chinese.
Do such organisms (with their apparent excess amounts of DNA) have more pseudogenes
among the members of their gene families?
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes
and alternative-splice variants.
The possibility of pseudogenes
and polymerase errors were eliminated by the translation of the sequences to amino acids and no stop codons or frame-shifts were found.
A study at the Weizmann Institute in Israel looked at smell receptor genes in 189 ethnically diverse volunteers, and found that each person had unique combinations of functioning pseudogenes
To date, the most difficult samples, such as microvariants (or mutations within DNA repeat sequences), mutations that are adjacent to secondary DNA structures, repeat regions, insertions, deletions, and scoring SNPs in genes found to have pseudogenes
have been successfully analyzed on the NanoChip(TM) Molecular Biology Workstation and its multi-use consumable, the NanoChip(TM) cartridge.
The genomic level includes information concerning genes and pseudogenes
, repeats, CpG islands, SNPs, enhancers, and promoters.
It consists of a menagerie of strange entities called pseudogenes
, retropseudogenes, satellites, minisatellites, microsatellites, transposons, and retrotransposons: all collectively known as 'junk DNA.