pseudogene

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pseudogene

[′sü·dō‚jēn]
(genetics)
A sequence of deoxyribonucleic acid resembling but not functioning like a gene; usually produced by gene duplication followed by mutations that alter or abolish function.
References in periodicals archive ?
It also addresses an additional issue unique to PMS2--the PMS2CL (PMS2 C-terminal like pseudogene) pseudogene (66).
Published in the latest issue of the journal Nature Structural & Molecular Biology, the team's findings suggest a much larger role for pseudogenes than previously thought -- a discovery that changes our understanding of the internal landscape of living cells, adding a new layer of complexity to an already crowded topography marked by multiple, overlapping, interacting gene networks.
influenzae and proposed as a candidate NTHI vaccine antigen, is present as a pseudogene in F3031 and F3047, as previously reported by Kilian et al.
1541) resequenced 54 genomic DNA fragments (43,675 bases) spanning four genes (CYP3A4, CYP3A5, CYP3A7, and CYP3A43), two pseudogenes (CYP3AP1 and CYP3AP2), and randomly selected inter-genic regions in samples from 24 Africans, 24 Caucasians, and 29 Chinese.
Do such organisms (with their apparent excess amounts of DNA) have more pseudogenes among the members of their gene families?
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
The possibility of pseudogenes and polymerase errors were eliminated by the translation of the sequences to amino acids and no stop codons or frame-shifts were found.
A study at the Weizmann Institute in Israel looked at smell receptor genes in 189 ethnically diverse volunteers, and found that each person had unique combinations of functioning pseudogenes.
To date, the most difficult samples, such as microvariants (or mutations within DNA repeat sequences), mutations that are adjacent to secondary DNA structures, repeat regions, insertions, deletions, and scoring SNPs in genes found to have pseudogenes have been successfully analyzed on the NanoChip(TM) Molecular Biology Workstation and its multi-use consumable, the NanoChip(TM) cartridge.
The genomic level includes information concerning genes and pseudogenes, repeats, CpG islands, SNPs, enhancers, and promoters.
It consists of a menagerie of strange entities called pseudogenes, retropseudogenes, satellites, minisatellites, microsatellites, transposons, and retrotransposons: all collectively known as 'junk DNA.