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purine
(redirected from Purine nucleoside phosphorylase)

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purine, type of organic base found in the nucleotides nucleotide (n`klēətīd', ny
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 and nucleic acids nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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 of plant and animal tissue. The German chemist Emil Fischer did much of the basic work on purines and introduced the term into the chemical literature in the early 20th cent. The two major purines of almost universal distribution in living systems are adenine adenine (ăd`ənĭn, –nīn, –nēn), organic base of the purine family.
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 and guanine guanine (gwä`nēn), organic base of the purine family.
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purine

Any of a class of heterocyclic compounds with a two-ring structure composed of carbon and nitrogen atoms. The simplest member, purine itself (C5H4N4), is not common, but its derivatives with the structure are. Examples are uric acid, caffeine, and two of the nucleotides in nucleic acids, guanine and adenine.


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Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems.
BioCryst is in clinical trials with its purine nucleoside phosphorylase inhibitor drug candidate, BCX-34, for T-cell related disorders such as psoriasis, cutaneous T-cell lymphoma and HIV.
 
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