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Purkinje Fiber

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Purkinje Fiber 

a cellular element found in the conduction system of ventricular myocardium; described in 1845 by J. E. Purkinje. Purkinje fibers are particularly large in ruminants. They have been studied mainly in mammals but appear to exist in other vertebrates as well. Although they are of muscular origin, Purkinje fibers have largely lost their contractile function and have become specialized in the conduction of excitation to contractile elements of the myocardium; this accounts for their meager number of myofibrils. Purkinje fibers are usually thicker than the contractile fibers of the myocardium and are rich in mitochondria and glycogen.



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Other topics include recent insights into the molecular pathophysiology of viral myocarditis, anti-platelet drugs, transplant arteriopathy, induction and patterning of the Purkinje fiber network, therapeutic angiogenesis for ischemic vascular disease, and diabetes mellitus.
The electrical impulses split here into the right and left bundles that travel through each side of the ventricles and wind up in the Purkinje Fibers which cause the ventricle to contract.
The complete response will include a previously completed in vitro hERG study as well as a canine Purkinje fibers study (Roden et al, Circ.
 
 
 
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