pyrogen

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pyrogen

[′pī·rə‚jən]
(biochemistry)
A group of substances thought to be polysaccharides of microbial origin that produce an increase in body temperature when injected into humans and some animals.
References in periodicals archive ?
2013) found autumnalis as the most prevalent serogroup followed by australis, pomona, canicola, pyrogens, icterohae-morrhagiae.
Reacting Vaccinated (n=148) Serogroups 100 200 400 800 1600 Autumnalis 3 2 2 5 7 Canicola 4 4 -- 3 1 Grippotyphosa 7 -- 1 -- 1 Icterohaemorrhagiae 7 2 3 2 -- Pomona 4 3 -- 2 -- Pyrogens 1 1 -- 2 3 Total 26 12 5 14 12 Reacting Un--vaccinated (n=105Total Serogroups 100 200 400 800 1600 Autumnalis 6 6 4 7 3 45 Canicola 2 4 1 1 -- 20 Grippotyphosa 1 -- 2 -- -- 12 Icterohaemorrhagiae 1 2 1 -- -- 18 Pomona 3 1 2 -- -- 15 Pyrogens 1 1 -- -- 1 10 Total 14 15 8 8 4 120
For analysis of the pyrogenic reactions, the PyroDetect System (EMD Millipore, Darmstadt, Germany), which is based on MAT, was used to assess pyrogens known to interact with different receptors on and in monocytes.
The monocytes activated by pyrogens produce cytokines which are detected in an enzyme-linked immunosorbent assay (ELISA).
Particulates, pyrogens and nucleases are captured on the polysulfone hollow fibers of the filter membrane and flushed out of the system via a reject stream.
The Pyrogen test result proved that HAp does not induce fever when injected into the blood system and once again this result is in line with our long-standing expectations regarding total biocompatibility of our HAp coating material which is at the heart of our technologies.
The Rabbit Pyrogen (Material Mediated) - ISO Test was performed by Toxikon Corporation in Bedford, Massachusetts, USA.
Six alternative cellular assays have therefore been developed to replace the rabbit pyrogen test and close the safety gap presented by use of the LAL test in controlling parenterals.
Ultrafiltration can be used for pretreating water going into an additional purification process or it can be used at the very end of the system to remove pyrogens.
If pyrogens are present in the test sample, the white blood cells in the blood respond by producing interleukin 1-beta, which is then measured by performing a standard ELISA assay.
The ability to detect pyrogens is critical in R&D settings where contaminated samples can skew test results and cause expensive delays in product development programs.