pyrogen

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pyrogen

[′pī·rə‚jən]
(biochemistry)
A group of substances thought to be polysaccharides of microbial origin that produce an increase in body temperature when injected into humans and some animals.
References in periodicals archive ?
For analysis of the pyrogenic reactions, the PyroDetect System (EMD Millipore, Darmstadt, Germany), which is based on MAT, was used to assess pyrogens known to interact with different receptors on and in monocytes.
The monocytes activated by pyrogens produce cytokines which are detected in an enzyme-linked immunosorbent assay (ELISA).
The Pyrogen test result proved that HAp does not induce fever when injected into the blood system and once again this result is in line with our long-standing expectations regarding total biocompatibility of our HAp coating material which is at the heart of our technologies.
The Rabbit Pyrogen (Material Mediated) - ISO Test was performed by Toxikon Corporation in Bedford, Massachusetts, USA.
To date, only the maker of Biogel(R) gloves have publicized that they conduct pyrogen (endotoxin) testing over their entire surgical glove range.
The ability to detect pyrogens is critical in R&D settings where contaminated samples can skew test results and cause expensive delays in product development programs.
It is the first in vitro test that is broadly effective in detecting pyrogens in virtually any therapeutic product - from traditional drugs, to blood products and biologicals, to materials used in medical devices.
MIVT:OTCBB), announced today that its proprietary Hydroxyapatite (HAp) ultra-thin "passive" stent coating has successfully passed the Rabbit Pyrogen Test (Material Mediated) - ISO confirming that the coating is non-pyrogenic and does not induce fever.