lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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.

Lipoic Acid

 

6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
(biochemistry)
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
20) It was emphasized in another review that lipoic acid, particularly R-lipoic acid, has a cholinergic neuroprotective effect and lipoic acid is a multimodal agent in AD.
Studies indicate R-lipoic acid inhibits cross-linking--the chemical formation of bridges between body proteins or other large molecules believed to contribute to aging through such processes as hardening of the arteries, reduction of skin elasticity that cause wrinkles and the stiffening of joints.
Studies show that giving older animals R-lipoic acid leads to improved metabolic function, healthier mitochondria, and reduced production of oxidative stress-inducing byproducts.
Many foods and nutritional supplements will increase intracellular levels of glutathione, such as R-lipoic acid, N-acetylcysteine, selenium, vitamins C and E, whey protein, and broccoli.
K-RALA (Potassium-R-Lipoate) is a stable, non-hygroscopic, non-polymeric potassium salt form of R-Lipoic Acid.
Newer precision techniques allow production of a pure R-lipoic acid, which provides a much more concentrated potency.
For more information about Insulow and research supporting the use of r-lipoic acid and biotin in the care and treatment of diabetes, please visit www.
Lynne Shinto and colleagues randomized 39 participants with Alzheimer's disease to receive a daily regimen consisting of fish oil concentrate, fish oil plus R-lipoic acid, or a placebo for one year.
Nutrient Typical Daily Dose CoQ10 as ubiquinol 100-200 mg Pyrroloquinoline quinone (PQQ) 10 mg Acetyl-L-carnitine arginate 675 mg R-lipoic acid 150 mg
An important animal study has now demonstrated that supplementation with R-lipoic acid reverses age-related accumulation of iron in rat brain tissue and restores normal antioxidant activity.
59) This translates into a 300 mg dose of R-lipoic acid to obtain the same biological activity.
124) Lipoic acid exists in two mirror-image forms: R-lipoic acid and S-lipoic acid.