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RANK ligand

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RANK ligand [¦raŋk ′līg·ənd]
(biochemistry)
A local paracrine factor that originates from osteoblasts and mediates the effects of most, if not all, agents that are known to impact osteoclast development in bone. Also known as osteoprotegerin ligand.


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In the next several months, if you have rheumatoid arthritis or osteoporosis, you will be hearing more about a substance called RANK ligand Let me explain In the next several months, if you have rheumatoid arthritis or osteoporosis, you will be hearing more about a substance called RANK ligand.
The relative ratio of OPG and RANK ligand in the bone marrow microenvironment may determine the number of active osteoclasts, bone resorption rate, and bone mass.
Increased bone resorption in SF mice was suggested by a trend towards increased mRNA expression of the pro-resorptive cytokine RANK ligand and significantly elevated serum TRAP levels.
 
 
 
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