osteosarcoma

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osteosarcoma

[¦äs·tē·ō·sär′kō·mə]
(medicine)
A malignant tumor principally composed of anaplastic cells of mesenchymal derivation. Also known as osteogenic sarcoma.
References in periodicals archive ?
9] Human genes: JAK3, Janus kinase 3; KRAS, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; GNAS, GNAS complex locus; AKT1, v-akt murine thymoma viral oncogene homolog 1; APC, adenomatous polyposis coli; MET, met protooncogene; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase; RB1, retinoblastoma 1; STK11, serine/threonine kinase 11; TP53, tumor protein p53; SMAD4, SMAD family member 4; ATM, ataxia telangiectasia mutated; IDH1, isocitrate dehydrogenase 1 (NADP+); NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog.
RB1 and p53 at the crossroad of EMT and triple-negative breast cancer.
We noticed overlapping genes from the analysis, and five genes (IL6, CHRNE, RB1, INHBA and NPPA) belonged to a red module.
Apartments are currently priced from pounds 159,950; A show apartment interior in the first phase of The River Buildings, RB1, now all sold
Multiplex PCR/liquid chromatography assay for detection of gene rearrangements: application to RB1 gene.
Sales of 500,000 tonnes per annum of a high quality export thermal coal RB1 specification coal product are forecast to commence in early Q4
Regions of loss were not associated with known tumor suppressor genes, such as RB1 or TP53 or CDKN2A.
The status of the RB1 genes of the patient and R51 cells have been studied previously [RB134 family in Ref.
Researchers have known for decades that loss of a tumor suppressor gene named RB1 launches retinoblastoma during fetal development.
48,52,53) The most common molecular alterations in squamous cell carcinoma are overexpression of cell cycle regulatory proteins (cyclin D1, cyclin E) and inactivation or loss of tumor suppressor genes such as TP53, RB1, and CDKN2A (p16 gene), which occur in up to 80% of cases.
Sales of 500,000 tonnes per annum of a RB1 specification, high
The work builds on previous studies that linked glioblastoma to disruptions in the RB1, p53 and Pten pathways, each of which has a key role in preventing tumor formation.