helicase

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helicase

[′hel·ə‚kās]
(biochemistry)
An enzyme that is capable of unwinding the deoxyribonucleic acid double helix at a replication fork.
References in periodicals archive ?
The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+dependent and require a functional Walker B motif in the helicase catalytic core.
RNA helicase p68 was first identified as 65 kDa protein (p65) by methylene blue-mediated cross-linking (MB-cross- linked) interacting with the U1snRNP when it was bound at5`ss of intron in spliceosome formation by Liu et al.
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs.
It is a 67 kDa tri-functional protein with a serine protease, an RNA helicase and NTPase activities (Fig.
In 2013 Rexahn expects to initiate a Phase I first-in-human clinical trial of RX-5902, an orally available, first-in-class inhibitor of p68 RNA helicase for the treatment of various solid tumors, such as melanoma and cancers of the ovary, kidney and pancreas.
The researchers are the first to make a recombinant EWS-FLI1 fusion protein, and use it to discover that the fusion protein stick to another protein, RNA helicase A (RHA)-a molecule that forms protein complexes in order to control gene transcription.
In July 2012 Rexahn submitted an IND for RX-5902, an exciting first-in-class p68 RNA helicase inhibitor that has considerable commercial potential.
Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.
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