RNA editing


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RNA editing

[¦är¦en¦ā ′ed·əd·iŋ]
(cell and molecular biology)
Alteration in the nucleotide sequence of messenger RNA after it has been transcribed from DNA, changing the nature of its protein product from what was encoded; may entail insertion, deletion, or enzyme-catalyzed chemical alteration of nucleotides.
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RNA editing of the type we study has also been demonstrated to be crucial for cancer progression.
Additionally, examples of RNA editing have been discovered before.
In addition, the RNA editing site (AAAAGG) for the processing of V and W proteins conserved in the phosphoprotein gene sequences of Hendra virus and Nipah virus was found, and 6 conserved domains within the L proteins of the order Mononegavirales (8) were found in the MojV L protein.
The discovery of RNA editing 25 years ago revealed a new layer of genetic information that provides organisms flexibility to explore sequence space that is not readily accessible through DNA mutations.
RNA editing of the microRNA-151 precursor blocks cleavag by the Dicer-TRBP complex.
Her most recent work attempted to correlate structural dynamics in the RNA editing process with primate evolution.
It includes extensive gene information and annotation, such as splice variants, antisense genes, SNPs, novel genes and RNA editing.
We also took into account the possibility of RNA editing, which can modify the start and stop positions (Kugita et al.
Compugen Ltd, Israel with its systematic identification of adenosine to inosine (A to I) RNA editing sites in the human transcriptome has increased the number of known (A to I) editing sites from approximately 100 to more than 10,000.
RNA editing, transport, and protein binding are becoming an increasingly well-understood important part of human disease.
It includes extensive gene information and annotation, such as: splice variants, antisense genes, SNPs, novel genes, RNA editing, etc.

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