rate-determining step

(redirected from Rate-limiting enzyme)
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rate-determining step

[′rāt di¦tər·mən·iŋ ‚step]
(chemistry)
In a multistep chemical reaction, the step with the lowest velocity, which determines the rate of the overall reaction.
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Abstract: Tryptophan 2,3-dioxygenase (TDO) exist only in liver while indoleamine 2, 3-dioxygenase (IDO) exists ubiquitously in the body, these are the most rate-limiting enzymes of kynurenine pathway (KP).
The D6-desaturase is the rate-limiting enzyme involved in HUFAs biosynthesis, which is responsible for the first step in the desaturation/elongation process in HUFAs synthesis.
Because [DELTA]-6 desaturase is the rate-limiting enzyme in formation of PUFA, the objectives of this study were the cloning, characterization and expression of the chicken [DELTA]-6 desaturase gene.
The mechanism(s) of such effects remains unknown and may be diverse but could include effects on DA release, on the DA transporter, and/or on the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in the DA synthesis pathway (Dluzen and McDermott 2000; Kuppers et al.
Glycogen synthase kinase (GSK3) regulates glycogen synthase, the rate-limiting enzyme in glycogen synthesis.
Immunoreactive antibodies directed against GABA and its rate-limiting enzyme glutamic acid decarboxylase (GAD) indicate that horizontal cells of the skate are most likely GABAergic (1).
Using protocols developed at Geron, hESCs were differentiated first into neural progenitors and then into neurons expressing thyrosine hydroxylase - the rate-limiting enzyme for the production of dopamine.
We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished levels of L-carnitine, which would adversely affect carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for fatty acyl-CoA uptake into mitochondria for beta]-oxidation.
In view of the fact that the statins inhibit the rate-limiting enzyme in cholesterol biosynthesis, there is likely to be a secondary depletion of metabolic intermediates formed during cholesterol synthesis.
In connection with this, heme-oxygenase, the rate-limiting enzyme involved in bilirubin production (2), may also play an important role.
But what some experts find even more compelling is the potential aliskiren might have for preventing end-organ damage, such as heart failure, because it works by blocking renin, the rate-limiting enzyme for the entire renin-angiotensin-aldosterone system (RAAS).

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