In view of the fact that the statins inhibit the rate-limiting enzyme
in cholesterol biosynthesis, there is likely to be a secondary depletion of metabolic intermediates formed during cholesterol synthesis.
The successful pairing of aliskiren with the diuretic hydrochlorothiazide was seen as a step forward for this agent--the first from a novel drug class--because it showed evidence of blocking renin, the rate-limiting enzyme
of the renin-angiotensin-aldosterone system.
A positive regulation of estradiol on the rate-limiting enzyme
for its synthesis comprises a positive feedback loop.
2), the first and rate-limiting enzyme
in the three-step pathway of uracil and thymine catabolism.
In addition, 3% of the hESC-derived neurons expressed tyrosine hydroxylase, the rate-limiting enzyme
for dopamine synthesis.
The effects of trimetazidine on glucose oxidation were accompanied by a 37% increase in the active form of pyruvate dehydrogenase, the rate-limiting enzyme
for glucose oxidation.
Entitled "Efficient inhibition of the Alzheimer's disease Beta-secretase by membrane targeting", the paper describes how Beta-secretase, the rate-limiting enzyme
in the production of Alzheimer's disease associated Beta-amyloid peptide, can be inhibited effectively using compounds anchored to cell membrane RAFTS.
But what some experts find even more compelling is the potential aliskiren might have for preventing end-organ damage because it works by blocking renin, the rate-limiting enzyme
for the entire renin-angiotensin-aldosterone system (RAAS).
33) showed that some ortho-substituted congeners inhibit tyrosine hydroxylase, the rate-limiting enzyme
in synthesis of the important neurotransmitter dopamine.
Vitamin B6 is an essential cofactor for the enzyme ornithine decarboxylase, the rate-limiting enzyme
in the formation of putrescine, which in turn regulates osteoblast glucose-o-phosphate dehydrogenase activity and thus osteoblast NADPH concentrations (3-6).
The previous studies from our laboratory showed that the age-dependent decline in GSH content in Fisher 344 rats was associated with a downregulation of glutamate cysteine ligase (GCL), the rate-limiting enzyme
in de novo GSH synthesis.
The mechanism is distinct from that of the statins, which clear cholesterol from plasma and inhibit the rate-limiting enzyme
in hepatic cholesterol synthesis.