Reed-Sternberg cell


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Related to Reed-Sternberg cell: Hodgkin's lymphoma

Reed-Sternberg cell

[′rēd ′stərn‚bərg ‚sel]
(pathology)
An anaplastic reticuloendothelial cell constituting the characteristic microscopic feature of Hodgkin's disease.
References in periodicals archive ?
The distinction between these 2 groups may become more challenging with the presence of scattered large cells that morphologically and immunophenotypically mimic the Reed-Sternberg cells of classical Hodgkin lymphoma.
The Reed-Sternberg cells are binucleated or multi-nucleated and must be present to make the diagnosis of Hodgkin's Disease.
Reed-Sternberg cells show golgi staining with CD15 and CD30 but are negative for the T- and B-cell markers.
Unlike the typical Reed-Sternberg cells of so-called classic Hodgkin disease, the L&H Reed-Sternberg cells characteristic of NLPHD are B cells by virtue of their expression of the B-cell-restricted antigen CD20.
In the vast majority of HLs, the neoplastic Reed-Sternberg cells are derived from germinal center or post germinal center B cells.
The nature of Reed-Sternberg cells and other malignant "reticulum" cells.
Biopsies of the lesion were consistent with Hodgkin's Lymphoma (HL), with Reed-Sternberg cells that stained positive by immunohistochemistry for CD15, CD30 and stained negative for CD45.
It showed nodular pattern of mixed cellularity type of Hodgkin lymphoma characterized by background of eosinophils, plasma cells and lymphocytes, some Reed-Sternberg cells (classic or mononuclear forms) with prominent large eosinophilic nucleoli (positive for CD15, CD30 and weakly PAX5, negative for S100, CD1a, CD20 and CD45), accompanied by LCH with diffuse neoplastic proliferation of Langerhans cells in other part (figure 2).
We report a case of advanced CHL with presence of Reed-Sternberg cells in the bone marrow where the diagnosis of CHL stage IIIB was made during childhood period.
Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma.
T-cell receptor PCR showed the presence of a clonal cell population and bone marrow histology revealed infiltration by tumour cells with scattered atypical uninucleated cells and binucleated Reed-Sternberg cells.
1,4,8,9 Multinucleated cells, such as Reed-Sternberg cells, may also be seen.