regulatory sequence

(redirected from Regulatory region)
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regulatory sequence

[′reg·yə·lə‚tȯr·ē ‚sē·kwəns]
(cell and molecular biology)
A sequence of deoxyribonucleic acid to which gene regulatory proteins bind to control the rate of transcription.
References in periodicals archive ?
Using its gene control platform, Syros identified subsets of AML and MDS patients with a highly specialized regulatory region of DNA, known as a super-enhancer, associated with either the RARA or IRF8 gene, or both.
In this paper, single nucleotide polymorphisms of 5' regulatory region and exon 1 of INHA gene were detected in one prolific goat breed (Jining Grey goat) and five low to medium fecundit y breeds (Boer, Liaoning Cashmere, Wendeng Dairy, Taihang and Inner Mongolia Cashmere goats) by PCR-SSCP and sequencing methods.
The early region of the HPV genome is downstream from the upstream regulatory region.
The primers are indicated "g" (direct genomic primer) and "r" (reversed genomic primer) and serve to monitor a successful PCR amplification of target regulatory region and for normalization of tissue DNA concentration.
We built luciferase reporter constructs containing WT (EYA4-P1 and EYA4-P2) and mutated (EYA4-M) sequences of the EYA4 regulatory region [Figure 2]a, bottom panel], and then co-transfected them with increasing amounts of empty or AML1-ETO-containing vectors into 293T cells.
in the coding region, the intron, the regulatory region for expression); whether the SNP affects a proteins sequence and, consequently, its function and activity; what diseases or cell processes are associated with the gene containing the SNP of interest; and whether there is any known clinical impact reported for a specific SNP.
There is an upstream regulatory region (URR) of 1000 bp without coding any proteins, that separates early and late genes.
Then, the effects of element-based promoter truncations in the upstream regulatory region of ChMT on the metal stress response were examined.
In this descriptive study, out of 98 clinical isolates of Mycobacterium tuberculosis at The Tuberculosis Research Center in the Iranian city of Arak, 64 isolates that had already been determined to be phenotypically resistant or susceptible to isoniazid were analyzed for mutations in the regulatory region of inhA-15 with 2 allele-specific polymerase chain reaction (AS-PCR) and sequence methods.
The circuit consists of the striatal-limbic system, which is involved in the brain's reward system in the striatum, and its stress system, in the amygdala; and the prefrontal regulatory region, which includes the medial prefrontal cortex (PFC), the anterior cingulate cortex (ACC), the orbitofrontal cortex (OFC), and the dorsolateral PFC.
The protein Chrono binds to the regulatory region of clock genes, with its repressor function oscillating in a circadian manner.
Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder.