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lagging strand
(redirected from Replication fork)

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lagging strand [′lag·iŋ ‚strand]
(cell and molecular biology)
In deoxyribonucleic acid (DNA) replication, the 3′ to 5′ DNA strand that is discontinuously synthesized as a series of Okazaki fragments in the 5′ to 3′ direction.
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Others have linked sensitivity to low doses of camptothecin to heightened sensitivity of cells in S phase (43) and have provided evidence that camptothecin-induced DSBs resulting from stalled replication forks are resolved by homologous recombination (39, 44).
Human Polynucleotide Kinase Participates in Repair of DNA ... by Feridoun Karimi-Busheri / Biological sciences community
In both cases, fluoroquinolones appear to trap the enzyme on DNA during the topoisomerization reaction, forming a physical barrier to the movement of the replication fork (4), RNA polymerase (5), and DNA helicase (6).
Emerging Mechanisms of Fluoroquinolone Resistance by Hooper, David C. / Emerging Infectious Diseases
The article, "A DNA Replication Mechanism for Generating Nonrecurrent Rearrangements Associated with Genomic Disorders," describes a newly discovered mechanism for human genomic disorders called replication Fork Stalling and Template Switching (FoSTeS) in which segments of DNA are added or deleted in previously unexpected locations during replication.
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