S100A6, S100A9, and S100A12 also have consistently high levels in samples of AD patients [135, 149].
Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models," Biochimica et Biophysica Acta (BBA)--Molecular Cell Research, vol.
S100A6 (calcyclin) is a calcium-binding protein of the S100 family, which has been isolated from melanocytes, Schwann cells, Langerhans cells, and dermal dendrocytes.
S100A6 (calcyclin) is a S100 subtype that stains Spitz nevi in a strong and diffuse pattern (Figure 7, C), whereas only one-third of melanomas express S100A6 and only in a weak and patchy pattern, with minimal to no reactivity at the junction.
Genes of diverse functional groups and signaling routes appeared: Cytoskleleton (BCL7A, DYNC1L12, SEFT10, SEPT11), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, POLR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), cell death (CASP2, INC2, MDM4, NAIP), DNA maintenance and processing (BAHCC1, FANCA, HIST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, TICAM2), transport functions (ABCC1, FXYD2, S100A6, SCNN1C, XP05), oxidative stress response (SPATS2L, GSTT2B, NQ01), blood coagulation (FGA, MATR3, PROCR, PIK3CG), and others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
434 S100A6 S100 calcium binding Calcium sensor protein A6 0.