SDS polyacrylamide gel electrophoresis
SDS polyacrylamide gel electrophoresis[¦es¦dē¦es ‚päl·ē·ə¦kril·ə·mīd ‚jel i‚lek·trō·fə′rē·səs]
(cell and molecular biology)
An electrophoretic technique in which proteins are denatured by the negatively charged detergent sodium dodecyl sulfate, which masks their intrinsic electrical charge so that when the constituent polypeptide chains are run through a polyacrylamide gel, the protein molecules are separated according to size, not electrical charge. Abbreviated SDS-PAGE.