It has been suggested that the excess of genetic information in DS patients is the cause of an increase in the activity of SOD1
in these patients (6, 7).
In addition, recent studies have suggested that the accumulation of mutant forms of SOD1
is linked to most sporadic cases of ALS.
MLST, performed using 8 unlinked genes from 6 randomly chosen strains, showed identical sequences for the CAPIO, GPD, LAC1, PLB1, SOD1
, IGSI, TEF1, and URE1 genes.
On the contrary, overexpression of SOD1
, SOD2 and CTT1 (cytosolic catalase T) at various combinations increased S.
Expression of SOD1
and the Cu-binding protein ceruloplasmin was increased in arsenic-exposed liver and in arsenic-induced liver tumors in the present work.
The work focuses on delivery to the spinal cord and brain to silence the SOD1
gene in ALS, and completion of the project is expected to generate supportive data for clinical development of anti-SOD1
Total SOD activity includes the activity of two SOD isoforms - SOD1
(Cu/ZnSOD) citoplasmatic and SOD2 (MnSOD) mitochondrial isoforms.
Pipeline candidates fall under major therapeutic classes such as glutamate receptor antagonists, SOD1
protein folding stabilizers, stem cell therapy, Sodium channel blockers, Interleukin-2 (IL-2) inhibitors, immunomodulators, dopamine antagonists, cell protectants, antioxidants, antibiotics and free radical scavengers.
Palmitoylation of SOD1
and the pathogenesis of ALS Principal Investigators: Raymond Roos, M.
Postischemic recovery of contractile function is impaired in SOD2 ([+ or -]) but not SOD1
([+ or -]) mouse hearts.
Key classes of mechanism of action include SOD1
protein folding stabilizers, dopamine agonists, immunomodulators and antioxidants.
Collaboration to Explore Recombinant Human-Derived Monoclonal Antibodies Targeting Misfolded SOD1