Als

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Related to SOD1: SOD2, SOD3, G93A

Als

(äls), Ger. Alsen, island, 121 sq mi (313 sq km), Sønderjylland co., S Denmark, in the Lille Bælt, separated from the mainland by the narrow Alensund. Sønderborg (partly situated on the mainland) is the main city; other towns include Augustenborg and Nordborg. Farming (particularly of apples and grain), fishing, dairying, and manufacturing (especially of motor vehicle parts) are the main occupations. Danfoss, a company that produces heating and refrigerating plants is there. Its beautiful beaches make the island a popular tourist attraction. It was held by Germany from 1864 to 1920.

ALS

Abbr. for “American Lumber Standards.”
References in periodicals archive ?
Three superoxide dismutases enzymes have been identified and characterized in mammals: cooper/zinc superoxide dismutase (Cu/ZnSOD encoded by SOD1 gene) manganese superoxide dismutase (MnSOD encoded by SOD2 gene) and the extracellular superoxide dismutase (ECSOD encoded by SOD3 gene) (Fridovich 1995; Miao and Clair 2009).
2008) ALS-linked mutant SOD1 induces ER stress--and ASK1-dependent motor neuron death by targeting Derlin-1.
Gene therapy is another promising area of research, including lentiviral-mediated gene therapy for improving motor neuron survival or small interfering RNA therapy for silencing mutant SOD1 expression (Azzouz, 2006; Wang et al.
While the SOD1 gene has long been known to play a role in familial ALS, scientists also suspected a connection to the more common form of ALS and sought to establish a shared pathological pathway, UMass said in a news release.
The Phase I study of ISIS-SOD1Rx is a placebo-controlled, dose-escalation study designed to assess the safety, tolerability and pharmacokinetic profile of ISIS-SOD1Rx in patients with familial ALS that is caused by mutations within the SOD1 gene.
If TDP-43 is the major pathway, then SOD1 was misdirecting us," says Christopher Shaw, a neurologist and neurogeneticist at King's College London.
Contrary to expectations, however, an increase of assembled NF-M and NF-H in perikarya of SOD1 mutant mice seems to ameliorate the disease, increasing life span for many months (Couillard-Despres et al.
Skeletal muscles are the primary target for the dominant action of the inherited SOD1 mutation.
About 10 percent of those who develop ALS have a family history of the disorder, and about 15 percent of these patients have a mutation in the SOD1 gene on chromosome 21.
Geotrygon saphirina: The following loci were fixed for the same allele in all taxa: CK, FUM, GDA, GLUD, GOT1, GOT2, [Alpha]GPD, GPI, ICD2, LDH, MDH1, MDH2, ME1, ME2, MPI, NADPH, PEPLA, PEP-LGG2, PGD, PGM1, PK, SOD1, SOD2, UNK.
GM604 also proved to be very effective in the disease modification in ALS animal model with mutant SOD1 gene.