SOS response


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SOS response

[¦es¦ō′es ri‚späns]
(genetics)
A bacterial deoxyribonucleic acid (DNA) repair system in which cell division and DNA replication are blocked, and DNA repair, recombination, and mutation genes are induced.
References in periodicals archive ?
Mutant bacteria with no functional SOS response were more vulnerable to the three classes of antibiotics studied.
In this context, exposure to agents which interfere with DNA replication or which are able to cause DNA damages, induces the expression of a set of genes designed SOS response.
The RecA filament promotes the LexA cleavage reaction inducing the expression of the SOS response genes (Kim et al.
LexA is a key regulator of the SOS response and we will use these new mutants to determine if regulation of the SOS response, the type III secretion system, and coronatine biosynthesis are linked.
Researchers have shown that the presence of antibiotics activates SOS response and thus increases concentration of RecA protein.
Figure 3 illustrates a literature-based linkage map between genes in the SOS response for the repair of DNA damage.
Finally, while rpoS and rpoD seem to be linked to the network, they appear to be under control of other genes in the network rather than exerting control over the SOS response.
Correlation of quinolone MIC and inhibition of DNA, RNA and protein synthesis and induction of the SOS response in Escherichia coli.
Bactericidal activities of five quinolones for Escherichia coli strains with mutations in genes encoding the SOS response for cell division.
The potential importance of a link between the SOS response and prophage induction for Stx1 and Stx2 expression has been reinforced by recent sequencing and pathogenicity studies (11,14,15).
Several of the agents tested here--the quinolones (21), trimethoprim (22), furazolidone, and metronidazole (23)--have a recognized capacity to induce bacterial SOS response, which is initiated when damaged bacterial DNA interacts with and activates the multifunctional RecA protein.
In what biologists call the SOS response, the bacterium activates a protein called RecA.