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Saha, Meghnad |
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Saha, Meghnad (māgnäd` sä`hä), 1893–1956, Indian physicist. He was a professor at Allahabad Univ. from 1923 to 1938 and a professor and physics department head at Calcutta Univ. from 1938. His theory of high-temperature ionization of elements and its application to stellar atmospheres, expressed in the Saha equation, is fundamental to modern astrophysics; subsequent development of his ideas has led to increased knowledge of the pressure and temperature distributions of stellar atmospheres. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| By inhibiting HDAC, SAHA increases the level of histone acetylation, resulting in increased expression of genes and proteins (such as p27kipl and gelsolin) that are directly implicated in tumor suppression. The most advanced therapeutic candidates such as SAHA and FK228 are already showing promising activity. Later this year, the Company plans to file an application for vorinostat, an investigational compound often referred to in the past as SAHA. |
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