Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to Sarcoidosis: lymphoma


A disease of unknown etiology characterized by granulomatous lesions, somewhat resembling true tubercles, but showing little or no necrosis, affecting the lymph nodes, skin, liver, spleen, heart, skeletal muscles, lungs, bones in distal parts of the extremities (osteitis cystica of Jüngling), and other structures, and sometimes by hyperglobulinemia, cutaneous anergy, and hypercalcinuria.



in man, a systemic granulomatous disease that affects various organs and tissues and produces a variety of symptoms. It was initially described as a skin disease in 1889 by the French dermatologist E. Besnier and the Norwegian dermatologist C. Boeck. Sarcoidosis was first studied as a systemic disease by the Swedish dermatologist J. Schaumann in the first quarter of the 20th century.

The etiology of sarcoidosis is unknown. The disease was once believed to be tuberculous in origin, but this theory has been abandoned by most specialists. Sarcoidosis seems to be similar to reticulosis. It affects the skin (sarcoids of Boeck and other manifestations), the peripheral lymph nodes, and, most commonly, the thoracic lymph nodes and the lungs. Sarcoidosis of the eyes is often in the form of iridocyclitis, and sarcoidosis of the bones is often in the form of osteitis fibrosa cystica. The nervous system and other organs are less commonly affected. There is no cardinal symptom.

Sarcoidosis is diagnosed on the basis of all available data. The disease process, which is usually chronic, is studied, as are the roentgenologic symptoms of pulmonary involvement. The morphological structure is examined: sarcoid granuloma, which consists of epithelioid, lymphoid, and giant noncaseating cells, is characteristic.

The prognosis is usually favorable, and spontaneous involution, especially of the thoracic lesions, is possible. Relapses are common. The prognosis is worse if pneumosclerosis has developed and if the eyes and central nervous system are involved. When the disease is not treated, the mortality rate is approximately 5 percent. Sarcoidosis is treated by the prolonged administration of corticosteroids.


Raben, A. S. Sarkoidoz. Moscow, 1964. (Bibliography.)
Lebacq, E. La sarcoïdose de Besnier-Boeck-Schaumann. Brussels, 1964.
5th International Conference on Sarcoidosis. Prague, 1971.


References in periodicals archive ?
11 Interstitial lung diseases were classified into different categories including IPF, non-specific interstitial pneumonitis (NSIP), hypersensitivity pneumonitis (HP), cryptogenic organising pneumonia (COP), sarcoidosis, connective tissue disease-associated interstitial lung disease (CTD-ILD) and other rare interstitial lung diseases depending upon the patient's clinical presentation, laboratory investigations, lung function tests, environmental exposures, radiological findings and pathological diagnosis if available.
Clinical symptoms of end-stage pulmonary sarcoidosis are nonspecific but generally include shortness of breath, dyspnea on exertion, and/or cough.
The true burden of sarcoidosis in India is not clearly known as reliable epidemiological data are not available.
An experimental model of sarcoidosis using Kveim tissue.
It provides the appropriate sampling particularly in the diagnosis of tuberculosis, organizing pneumonia (OP), and respiratory bronchiolitis in which the involvement of the disease is apparent in the center of or around the bronchioles and in the diagnosis of some diseases such as lymphangitis carcinomatosa and sarcoidosis which have involvement throughout the lymphatic distribution (2).
Sarcoidosis was found to be compatible with the condition after excluding tuberculosis.
Presentamos el caso de una paciente con sarcoidosis con compromiso cardiaco, incluyendo la descripcion de las medidas terapeuticas aplicadas y la evolucion posterior.
Methods: The data of 84 patients diagnosed with pulmonary sarcoidosis in our clinic between 2011 and 2014 were evaluated retrospectively.
Dr Lalit Duggal, senior rheumatologist at Sir Ganga Ram Hospital, said people also suffer from sarcoidosis, a disease triggered by several environmental factors, one of them being air pollution.
Next, two authors independently searched PubMed, Embase, The Cochrane Library, Wanfang, Cqvip, and CNKI using the following search terms: sarcoidosis AND (“endobronchial ultrasound-guided transbronchial needle aspiration” AND “transbronchial needle aspiration”) OR (“endobronchial ultrasound-guided transbronchial needle aspiration” AND “endobronchial biopsy”) OR (“endobronchial ultrasound-guided transbronchial needle aspiration” AND “transbronchial lung biopsy”) OR (ultrasound AND biopsy) OR bronchoscopy OR “endoscopic ultrasound-guided fine needle aspiration” OR endosonography.