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A disease of unknown etiology characterized by granulomatous lesions, somewhat resembling true tubercles, but showing little or no necrosis, affecting the lymph nodes, skin, liver, spleen, heart, skeletal muscles, lungs, bones in distal parts of the extremities (osteitis cystica of Jüngling), and other structures, and sometimes by hyperglobulinemia, cutaneous anergy, and hypercalcinuria.



in man, a systemic granulomatous disease that affects various organs and tissues and produces a variety of symptoms. It was initially described as a skin disease in 1889 by the French dermatologist E. Besnier and the Norwegian dermatologist C. Boeck. Sarcoidosis was first studied as a systemic disease by the Swedish dermatologist J. Schaumann in the first quarter of the 20th century.

The etiology of sarcoidosis is unknown. The disease was once believed to be tuberculous in origin, but this theory has been abandoned by most specialists. Sarcoidosis seems to be similar to reticulosis. It affects the skin (sarcoids of Boeck and other manifestations), the peripheral lymph nodes, and, most commonly, the thoracic lymph nodes and the lungs. Sarcoidosis of the eyes is often in the form of iridocyclitis, and sarcoidosis of the bones is often in the form of osteitis fibrosa cystica. The nervous system and other organs are less commonly affected. There is no cardinal symptom.

Sarcoidosis is diagnosed on the basis of all available data. The disease process, which is usually chronic, is studied, as are the roentgenologic symptoms of pulmonary involvement. The morphological structure is examined: sarcoid granuloma, which consists of epithelioid, lymphoid, and giant noncaseating cells, is characteristic.

The prognosis is usually favorable, and spontaneous involution, especially of the thoracic lesions, is possible. Relapses are common. The prognosis is worse if pneumosclerosis has developed and if the eyes and central nervous system are involved. When the disease is not treated, the mortality rate is approximately 5 percent. Sarcoidosis is treated by the prolonged administration of corticosteroids.


Raben, A. S. Sarkoidoz. Moscow, 1964. (Bibliography.)
Lebacq, E. La sarcoïdose de Besnier-Boeck-Schaumann. Brussels, 1964.
5th International Conference on Sarcoidosis. Prague, 1971.


References in periodicals archive ?
9) Iris nodules and 'mutton fat' keratic precipitates are a feature of granulomatous disease such as sarcoidosis, tuberculosis (TB) or syphilis (see Figure 1) and sectorial iris atrophy is common in herpetic infections.
The incidence of sarcoidosis in the United States is high, and sarcoidosis-related mortality is increasing (27, 28).
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The idea to use Kiacta as a treatment for chronic sarcoidosis was developed by Dr Adam S Morgenthau, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.
This article also provided us with a good opportunity to explain the rare association between sarcoidosis and IgA nephropathy.
Sarcoidosis is a systemic, chronic, granulomatous disease affecting most commonly the lungs and lymphatic system.
Therefore, all patients presenting to the dermatology departments with cutaneous sarcoidosis require investigations for systemic sarcoidosis.
In an effort to raise more awareness of the illness and cash for the charity SILA - which offers support and information to sufferers of sarcoidosis - the couple are taking part in an 18-mile coastal walk from Sandsend to Skelton on Sunday - it had been planned for last Sunday but was cancelled due to the weather.
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