Sarcosine


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Related to Sarcosine: Glycine

sarcosine

[′sär·kə‚sēn]
(organic chemistry)
CH3NHCH2COOH Sweet-tasting, deliquescent crystals; soluble in water, slightly soluble in alcohol; decomposes at 210-215°C; used in toothpaste manufacture. Also known as methyl glycocol.

Sarcosine

 

(also N-methylglycine), CH3NHCH2COOH, a methyl derivative of the amino acid glycine. It is an intermediate metabolic product, serving in the body as a source of methyl groups in transmethylation reactions. Sarcosine is a component of creatine in the muscles and of the group of antibiotics called actinomycins.

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Sarcosine and alanine were quantified in plasma by gas-chromatograph mass spectrometry.
It is very easy to identify sarcosine in urine, which is a less invasive test than the blood analysis needed for the standard prostate-specific antigen (PSA).
Tests for elevated sarcosine also outperformed the most widely used clinical test for detecting prostate cancer.
HHMI investigator Arul Chinnaiyan and colleagues at the University of Michigan showed that as prostate cancer develops and progresses, sarcosine levels increase in both tumour cells and urine samples, suggesting that measurements of the metabolite could aid in non-invasively diagnosing the disease.
N-acyl sarcosinates are excellent candidates for these environmentally-conscious cleaners as they are produced by the reaction of the amino acid sarcosine with a fatty acid chloride.
5 M EDTA, 1% N-lauroyl sarcosine, 1 mg/mL Proteinase K; pH 8.
Other prostate cancer-specific genes, includingPCA3 (prostate cancer antigen 3) (6), [6] TMPRSS2-ERG (transmembrane protease, serine 2) (7), DNA methylation (8), ERG (v-ets erythroblastosis virus E26 oncogene homolog) (9), annexin A3, and sarcosine, some of which have been proposed in combination (10, 11), have raised enthusiasm throughout the scientific community.
We now manufacture the entire Hamposyl line of specialty anionic surfactants--the N-acyl sarcosines and their salts, the sarcosinates--using the still-unique Schotten-Baumann technology to react the amino acid sarcosine with a fatty acid chloride," he said.
the leader in metabolomics-driven biomarker discovery and analysis, today announced that it has released mFocus TST[TM] (Tissue-based Sarcosine Test), a research use only assay that measures the level of sarcosine in a biological sample.
Folate (5-methyltetrahydrofolate), riboflavin, flavin mononucleotide (FMN), [7] FAD, pyridoxal 5'-phosphate (PLP), pyridoxal (PL), pyridoxic acid, free choline, betaine, dimethylglycine, creatinine, methionine sulfoxide, arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), tryptophan, kynurenine, kynurenic acid, anthranilic acid, 3-hydroxykynurenine, xanthurenic acid, 3-hydroxyanthranilic acid, and formiminoglutamic acid, were determined by liquid chromatography--tandem mass spectrometry (14-17), and methylmalonic acid, total homocysteine, total cysteine, methionine, serine, glycine, cystathionine, and sarcosine by gas chromatography-tandem mass spectrometry (15, 18).