Sarcosine


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Related to Sarcosine: Glycine

sarcosine

[′sär·kə‚sēn]
(organic chemistry)
CH3NHCH2COOH Sweet-tasting, deliquescent crystals; soluble in water, slightly soluble in alcohol; decomposes at 210-215°C; used in toothpaste manufacture. Also known as methyl glycocol.

Sarcosine

 

(also N-methylglycine), CH3NHCH2COOH, a methyl derivative of the amino acid glycine. It is an intermediate metabolic product, serving in the body as a source of methyl groups in transmethylation reactions. Sarcosine is a component of creatine in the muscles and of the group of antibiotics called actinomycins.

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with 1,10- phenanthroline and some biologicaly important amino acids like glycine, L-Valine and Sarcosine (N-methyl glycine) as lignds have great socio economic importance and unique significance in the field of biochemistry.
We present measurements in plasma of prostate cancer patients characterised by PSA, tumour stage and Gleason score using GC/MS for sarcosine methodology (9,10) to elaborate further on the suitability of sarcosine as a marker for prostate cancer.
Sarcosine (N-methylglycine) is a naturally occurring GlyTl inhibitor that has been used in early clinical trials in Taiwan.
Later, a 2 per cent N-lauroyl sarcosine was added to this reaction mixture and incubated for one hour.
Arun Sreekumar, the study not only proves that sarcosine is a marker of cancer aggressiveness, but also that it is highly associated with tumour development as well.
The latest study links a substance called sarcosine - produced by the body - to the tiger strain.
They also found that this molecule, known as sarcosine, may be associated with prostate cancer invasiveness and aggressiveness.
Urine creatinine concentrations were measured using Creatinine Plus Assay, which is a coupled enzymatic reaction using creatininase, creatinase, and sarcosine oxidase (Roche Diagnostic, Indianapolis, Ind).
Lam-otrigine has received the most attention; other agents include glycine, D-alanine, and sarcosine.
5% sodium lauryl sarcosine [Sarcosyl, Kodak International Biotechno-logies, New Haven, CT, USA], 1 mg/mL lysozyme [Life Technology, Sigma-Aldrich, Steinheim, Germany], and 7 [micro]g/mL lysostaphin [Sigma]), then incubated overnight at 55[degrees]C in 4 mL Lysis 2 buffer (1% sodium lauryl sarcosine [Sarcosyl], 0.
This method allowed determination of concentrations of 20 common amino acids, as well as phosphoserine (P-Ser), taurine (Tau), urea, citrulline (Cit), sarcosine (Sar), [alpha]-aminoadipic acid ([alpha]-AAA), [beta]-alanine ([beta]-Ala), [beta]-aminoisobutyric acid ([beta]-AiBA), [gamma]-aminoisobutyric acid (GABA), ethanolamine (EtON[H.