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second messenger
(redirected from Second messenger system)

   Also found in: Medical, Wikipedia 0.01 sec.
second messenger [′sek·ənd ′mes·ən·jər]
(cell and molecular biology)
Any small molecule or ion that occurs in the cytoplasm of a cell, is generated in response to a hormone binding to a cell-surface receptor, and activates various kinases that regulate the activities of other enzymes.


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One drug which we know directly affects the second messenger system is lithium, which directly affects activation of protein kinase C, which in turn activates protein synthesis of .
This results in partnering of two genes, namely BCR and ABL (which encode a tyrosine kinase involved in second messenger systems controlling growth and proliferation.
We are particularly interested in the signaling cascade that utilizes the phospholipase C b4 (PLCb4) second messenger system.
 
 
 
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