selectin


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selectin

[sə′lek·tən]
(cell and molecular biology)
Any of a family of carbohydrate-binding, calcium-dependent cell adhesion molecules that play an important role in leukocyte-endothelial binding.
References in periodicals archive ?
In leukocyte adhesion deficiency syndrome (LAD), a genetic defect either in [beta]2 integrins (type I) or in fucosylated selectin ligands (type II), leukocytes cannot stop or roll, respectively; this syndrome is characterized by marked leukocytosis and frequent bacterial infections.
Circulating selectin including sE-selectin is known to inhibit lymphocyte adhesion to the endothelium at a high enough concentration (Nielsen and Lyberg, 2004).
In experiments with diluted whole blood spiked with a known concentration of hematopoietic cancer cells, the mixture of selectins and antibodies yielded significantly higher recoveries of CTCs than with antibodies alone.
Clinical and biochemical values in CAD patients with selectin genotypes Characteristics Genotype S/S (n=273) S/R (n=56) Age 57.
Selectin binding is characterized by fast associations, which allows cells to be recruited from fastmoving blood flow to the endothelium (33).
Plasma samples stored at -80[degrees] C were thawed and assayed using 96-well immunoassay kits for the proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-cc (TNF-ra) (Quantikine HS, R&D Systems, Minneapolis, MN), soluble TNF-a receptor II (sTNF-RII) (Quantikine, R&D Systems), the acute-phase protein C-reactive protein (CRP) (Zymutest, Hyphen BioMed, Neuville-sur-Oise, France), and a marker of platelet activation, soluble platelet selectin (sP-selectin) (Jurk and Kehrel 2005).
A third type, the selectins, pierces the outer cell membrane in the form of a single zigzag.
By inhibiting selectin interactions, GMI-1070 may be able to decrease the enhanced cell adhesion that results in vaso-occlusive crisis.
GMI-1070 is thought to inhibit selectin interactions, a key early step in the inflammatory process leading to vaso-occlusive crisis.
About SelG1 SelG1 is an investigational humanized monoclonal antibody directed against P-selectin, a key member of the adhesion molecule family known as the selectins.
Energid's Actin (TM) and Selectin (TM) products provide advanced technology in the form of extensible software toolkits.
Specifically, rolling is mediated by adhesion under shear stress of the selectin family of endogenous lectins to their carbohydrate ligands on cell-surface glycoproteins.