sendmail's configuration file, which it reads once when starting up, usually found in the /etc directory.

Only real Unix Gurus can understand, let alone modify, this file since it consists moslty of header rewrite rules written as M4 macros, as well as various other one- or two-character commands.
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According to Jared Vogt, president of MetaInfo, "We chose to port Sendmail directly from UNIX to retain interoperability, flexibility and extensible nature of the sendmail.