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a piece of tissue that has died as a result of a circulatory disorder and become separated from the surrounding healthy tissue. A sequestrum may develop, for example, during osteomyelitis. Sequestration may also occur in lung, tendon, or muscle tissue. While in the body, a sequestrum continuously promotes the suppurative process. A sequestrum may be discharged from the body with the flow of pus; sometimes, however, it is necessary to remove it surgically