serine protease


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serine protease

[¦se‚rēn ′prōd·ə‚ās]
(cell and molecular biology)
A family of endopeptidases whose proteolytic activity involves the hydroxy group of the serine residue; they play an important role in digestion, blood clotting, and the complement system.
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References in periodicals archive ?
There are different mechanisms for controlling serine protease activity to avoid any unwanted protein degradation and to allow spatial and temporal regulation of proteolytic activity.
TMC435350 is a potent inhibitor of the hepatitis C virus (HCV) NS3/4A serine protease and is presently in a phase IIa proof-of-concept trial (OPERA- 1) in Europe.
Recently, three other members of this family, hK6 (also known as neurosin), hK10 [also known as normal epithelial cell specific 1 (NES1)], and hK11 [also known as trypsin-like serine protease (TLSP)], have been shown to be potential biomarkers for ovarian and prostate cancer (4-6).
The two posters are titled "Results of a phase I placebo-controlled trial in healthy volunteers to examine safety, tolerability and PK of the protease inhibitor TMC435350 after single and repeated dosing" and "In vitro activity and preclinical PK of a potent HCV NS3/4A serine protease inhibitor, TMC435350".
Experimental evidence has also shown that hK2 and hK4 can activate the proform of another serine protease, uPA (44, 50).
DPP4 is a serine protease that has emerged as an important target for the treatment of type 2 diabetes.
Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression.
proteinase k is a broad-spectrum serine protease that can hydrolyse keratin.
Anti-plasma serine protease inhibitor (SERPINA5), hepatocyte growth factor activator (HGFAC), anti-leucine zipper protein 4 (LUZP4), and anti-phosphoinositide phospholipase C (PLCH2) were used (Abcam, USA).
The plant protease inhibitor (PI) interaction with serine proteases in insects from a stable and inactive acyl-enzyme distort the serine protease active site (catalytic triad).
Molecular cloning, characterization and expression analysis of a chymotrypsin-like serine protease from kuruma shrimp Marsupenaeus japonicus.
Patients who improved the most on doxycycline also had the lowest activity of serine protease and matrix metalloprotease (MMP) in their skin, reported Anna Di Nardo, MD, PhD, of the University of California San Diego in La Jolla.

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