Shikimic Acid


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shikimic acid

[shə′kim·ik ′as·əd]
(biochemistry)
C7H10O5 A crystalline acid that is a plant constituent, and an intermediate in the biochemical pathway from phosphoenolpyruvic acid to tyrosine.

Shikimic Acid

 

the most important intermediate product of metabolism in microorganisms and higher plants; colorless crystals, with a melting point of 184°C and good solubility in water.

The biochemical role of shikimic acid was elucidated in 1955–58 by the American microbiologist B. Davis while working with mutants of Bacillus coli. The formation of the acid is related to carbohydrate metabolism; its closest precursor is 7-phosphate-3-deoxyarabinoheptulose. Shikimic acid takes part in the biosynthesis of aromatic acids, including the amino acids phenylalanine, tyrosine, and tryptophan; phenol compounds, including phenol alkaloids; coumarins; lignin; and flavonoid pigments and other secondary metabolites.

REFERENCES

Zaprometov, M. N. Osnovy biokhimii fenol’nykh soedinenii. Moscow, 1974.
Biokhimiia rastenii. Moscow, 1968. (Translated from English.)
References in periodicals archive ?
We have come up with new indigenous processes of shikimic acid production for large- scale validation.
Rap biosynthesis in media enriched with different concentrations of shikimic acid and CaP.
Shikimic acid production by a modified strain of E.
However, growing demand for the drug has put pressure on the supply of shikimic acid, the raw material now used in making the drug.
Khoja also stressed that it would not be proper to consider anise more useful than Tamiflu because it contains Shikimic acid, which is also in Tamiflu.
BioFlu Immune Support combines a selection of four of the most powerful, natural antioxidants: Black Elderberry, shown in human trials to reduce the severity of flu symptoms by 50%; Siberian Ginseng; Star Anise; and Shikimic Acid, the plant from which the leading antiviral drug Tamiflu is made.
Star anise, star aniseed, or Shikimic acid, a primary feedstock used to create the anti-flu drug Tamiflu, is produced by most autotrophic organisms, but star anise is the industrial source.
Now a project has been launched to find ways of extracting the shikimic acid, from Welsh-grown sitka spruce.
5 4 Enzymes tried Esterase (EST), Glucose-6-phosphate dehydrogenase (G6PDH), Malate dehydrogenase (MDH), Malic enzyme (ME), 6-phosphogluconate dehydrogenase (6PGDH), phosphoglucoisomerase (PGI), phosphoglucomutase (PGM), menadione reductase (MR), shikimic acid dehydrogenase (SKDH).
For several years Roche Pharmaceuticals has made the drug with shikimic acid from the pod of the star anise tree, a native of Asia.
And whereas the original yield from shikimic acid [the key input] to oseltamivir was 10 to 12 percent by weight, with the newer methods you can get between 30 and 50 percent.
The other requires specialized lab equipment to measure metabolite levels in leaf tissue samples, because glyphosate inhibits plants' amino acid metabolism in what's known as the shikimic acid pathway.