is identified on frozen section as a fine to coarse, dark brown pigment in periportal hepatocytes, and in severe cases becomes panlobular in distribution.
involves hemosiderin deposition on the surface of the brain, cord and cranial nerves.
It shows typical hypointense rim on both T1 and T2 weighted images representing siderosis
The most important clinical conditions involving primary and secondary iron overload leading to iron-mediated tissue damage are genetic hemochromatosis and transfusional siderosis
The information obtained from patients' medical records included demographic data (age, sex, race), anti-HCV result, qualitative/quantitative polymerase chain reaction (PCR) for HCV, HCV genotyping, HBV serological data (HBsAg, anti-HBc, anti-HBs), ultrasound and liver biopsy findings (fibrosis, steatosis, siderosis
, cirrhosis), previous HBV or HCV treatment (treatment duration, drugs used, response to therapy), date of HIV infection, HIV viral load (lastresult), [CD4.
The two cases illustrated here represent classic GGBs, the first in an atrophic spleen (50 grams) of a patient with known sickle cell disease, hepatomegaly (liver: 2,700 grams), and hepatic siderosis
; the second in the spleen of a patient with end-stage cirrhosis, marked splenomegaly (spleen: 830 grams), and marked, systemic siderosis
Baritosis (barium), stannosis (tin), and siderosis
(iron) are radiopaque dust exposures that cause small lung nodules.
The primary purpose of this article is to provide an in-depth review of these "extras" that one should assess in liver biopsies with chronic hepatitis, namely steatosis, siderosis
, concomitant diseases, and features associated with an increased risk of hepatocellular carcinoma (HCC).
The term superficial siderosis
is used to describe the haemosiderin deposition on the surface of the brain, spinal cord, brainstem and cranial nerve leptomeninges following recurrent subarachnoid haemorrhage.
Various effects have been reported for TNF-[alpha] -308A allele carrier status in hemochromatosis, including lower prevalence of liver cirrhosis (33), no effect on liver cirrhosis, siderosis
, or serum ferritin concentration (34), and slightly increased collagen concentrations in liver tissue (35).
bulbi as a result of iron retention is characterized by rust coloured corneal stroma, iris heterochromia, mydriasis, decreased vision, lenticular deposits, cataract, retinal degeneration and glaucoma.
2% of group 2 patients, and hepatic siderosis