silent mutation

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Related to Silent gene: Silent mutation

silent mutation

[′sī·lənt myü′tā·shən]
(genetics)
A mutation that does not result in amino acid sequence change.
References in periodicals archive ?
Thus, these subjects were definitely homozygous for the silent gene of BCHE.
Silent genes tend to be packaged as heterochromatin whereas active, functional genes are in euchromatin.
The fact that silent genes can be "primed" for expression was no surprise: researchers knew that the enzymatic machine that copies DNA into the RNA blueprint for proteins--a protein called Pol II--often pauses at the start of a gene, presumably revving its engine in preparation to jump across the genetic start gate in response to a developmental signal.
Here, it was shown that the pBCTPOKI-6 vector with a 6 kb long arm is more efficient in homologous recombination events than the pBCTPOKI-10 vector with a 10 kb long arm, indicating that optimization of targeting vector construction may be required for successful gene-targeting of transcriptionally silent genes in the somatic cells.
Butyrylcholinesterase genes in individuals with abnormal inhibition numbers and with trace activity: one common mutation and two novel silent genes.