Sphingosine


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Related to Sphingosine: cerebroside, ceramide, sphingomyelin

sphingosine

[′sfiŋ·gə‚sēn]
(biochemistry)
C18H37O2N A moiety of sphingomyelin, cerebrosides, and certain other phosphatides.

Sphingosine

 

an unsaturated higher aliphatic amino alcohol, C13H27CH=CHCH(OH)CH(NH2)CH2OH. Sphingosine is soluble in organic solvents and insoluble in water; its melting point is 81.5°–83°C, and its properties are those of a base. Sphingosine occurs in nature as a constituent of sphingolipids. Its biosynthesis in cells is effected from the amino acid serine and palmitic acid with the participation of coenzyme A. Sphingosine exhibits an anticoagulant effect since it inhibits the conversion of prothrom-bin to thrombin. The more than 60 analogues of sphingosine— sphingosine bases—are distinguished by the length of the aliphatic chain, the degree of nonsaturation, the type of branching, and the location of the double bond.

References in periodicals archive ?
Uno de los principales componentes de las balsas lipidicas son los esfingolipidos, a partir de los cuales se generan ceramidas y esfingosina, la cual puede ser fosforilada por una kinasa de esfingosina (SphK, sphingosine kinasa) generando esfingosina 1-fosfato (S1P) (61).
Ceramidases play a vital role in ceramide pathway that metabolize ceramide into sphingosine, and in turn, generate an anti-apoptotic metabolite sphingosine-1-phosphate (Vejselova et al.
Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin.
The report provides comprehensive information on the Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Fingolimod, an oral sphingosine 1-phosphate receptor modulator that is approved for MS treatment, is also associated with the development of macular edema in patients.
Two matriptase activation inducers such as lysophospholipid-derivative, sphingosine 1-phosphate (S1P), and polyanionic compound, suramin, were found to act cell-type specifically [13].
Ceramides composed of fatty acids and sphingosine, located in the membrane of cells in great concentration, are critical to the barrier properties of the skin, preventing harmful chemicals, toxins and bacteria and limiting loss of water and nutrients.
Receptos comes with Ozanimod, a novel, potential best-in-class, oral, selective sphingosine 1-phosphate 1 and 5 receptor modulator to Celgene's deep and diverse pipeline of potential disease-altering medicines and investigational compounds.
catalyzed) by an enzyme called sphingosine kinase 1, which is an important regulator of tumor progression in melanoma and several other cancers (Meng et al.
21) Ceramides comprise a family of waxy lipids composed of sphingosine and a fatty acid that fill in the intercellular spaces of the stratum corneum to serve as the mortar component of the "brick and mortar" barrier.
Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.
PDGF/PDGFR-B directs cell migration with both sphingosine kinase activation and expression of endothelial differentiation gene-1 (Rosenfeldt et al.

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