To accomplish this goal, the stimulating contacts on both designs are located on the medial surface of the electrode and two very different strategies are used to position the electrode closer to the spiral ganglion in situ.
These studies examined electrodes with and without insulating carriers, with stimulating contacts in different orientations, and with these contacts in varying proximity to the spiral ganglion.
Thus, even minor damage to the modiolar wall may cause loss of spiral ganglion cells as a result of direct trauma and could also provide a pathway for the spread of infection from the middle ear, along the CI carrier, and into the cerebrospinal fluid, potentially leading to severe medical complications.
Stakhovskaya and colleagues provide a map of frequency distribution along the length of the spiral ganglion and insights that may be important in future electrode array design .
the inner hair cells), (2) that the infused neurotrophin protects the auditory neurons of the spiral ganglion from cell death induced by neurotrophin molecule withdrawal, and (3) that either BDNF or neurotrophin-3 stimulated neuritic overgrowth of the VIIIth cranial nerve peripheral processes.
c-Jun) in dissociated cell cultures of the rat spiral ganglion that had been exposed to oxidative stress with cisplatin.
Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss.
These findings may provide the first step toward regenerating spiral ganglion
neurons, the nerve cells that send sound representations to the brain," said Dr Alain Dabdoub, co-investigator and assistant professor of surgery with the division of otolaryngology at the UC San Diego School of Medicine.