In the ITG group, pyknotic spiral ganglion cells were seen in light microscopy examination.
Histopathological findings in the ITG group were cor-related with the ABR findings showing apoptosis in the cochlea and spiral ganglion cells.
These findings are particularly interesting as they show that spiral ganglion
stem cells can be propagated in vitro," Bioresearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland said in a news release.
Marc Diensthuber and coauthors from Goethe-University (Frankfurt, Germany), Justus-Liebig University (Giessen, Germany), Harvard Medical School and Massachusetts Eye and Ear Infirmary (Boston, MA), and Harvard University and MIT (Cambridge, MA), conclude that the self-renewing properties demonstrated by spiral ganglion
stem cells make them a promising source of replacement cells for therapies designed to regenerate the neural structures of the inner ear in the article "Spiral Ganglion
Stem Cells Can Be Propagated and Differentiated Into Neurons and Glia"
Even in cases of moderate severity, intracochlear trauma may result in reduced numbers of functional peripheral dendrites or spiral ganglion cells, idiosyncratic distribution of these cells, and large variation in the efficiency of stimulating sites along the length of the implanted array.
One contact of each pair was oriented on the medial side of the electrode carrier toward the position of the spiral ganglion, and the second contact was oriented on the upper surface of the carrier toward the osseous spiral lamina or basilar membrane.
The animals' spiral ganglion neurons had been deliberately destroyed with a drug called ouabain, leaving them completely deaf.
Post mortems showed that the stem cells turned into specialised spiral ganglion neurons in the ear.
Calpain inhibitors have been shown to significantly protect spiral ganglion
neurons from damage by hypoxia and neurotrophin-withdrawal-induced apoptosis.
They have found that Sox2, a protein that regulates stem cell formation, is involved in spiral ganglion