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Enlargement of the spleen.



in medicine, the enlargement of the spleen. Splenomegaly occurs with diseases of the spleen (tumors, cysts, abscesses), with general infections (sepsis, malaria, typhoid fever, typhus), with blood diseases (leukoses, lymphgranulomatos-es), and with liver diseases. The spleen is examined by palpation while the individual is lying on his side; it will not be felt if its size is normal.

Splenomegaly is often the first manifestation of blood disease. In such cases, splenic puncture is performed in order to make an accurate diagnosis. With chronic leukoses, the spleen may occupy most of the abdomen and weigh as much as 8 kg. Splenomegaly is accompanied by disruption of breathing, blood circulation, and the functions of adjacent organs, including the stomach, intestine, and left kidney. Disturbances of splenic blood circulation (thromboses), suppression of hematopoiesis (hypersplenism), and other complications may also occur. The condition is treated by surgically removing the spleen (splenectomy), by irradiating the spleen with gamma rays, and by administering cytostatics and corticosteroids.

References in periodicals archive ?
Mohanty et al (2004) found hepatomegaly in 72% cases and splenomegaly in 80% cases respectively.
One 4 x 4 x 3 cm indurated mass [Figure 3] at the pancreatic tail constricted the splenic vein and was considered to be associated with splenomegaly and torturous engorgement of the short gastric and gastroepiploic veins.
Of these, four met the criteria for Tropical Splenomegaly, as it was known at the time, three of them were brothers, underscoring the importance of genetic predisposition in tribal HMS.
19] Hypofibrinogenaemia (in the absence of liver failure or laboratory features of DIC) suggests immune dysregulation and should arouse suspicion of HLH, especially if associated with splenomegaly.
A 49-year-old African-American male with a past medical history of the alpha thalassemia trait who had a three-year history of marginal zone monocytoid B-cell non-Hodgkin lymphoma (NHL), which was diagnosed on a lymph node and bone marrow biopsies, had a longstanding splenomegaly with symptoms of fever, night sweats, fatigue, weight loss, mild abdominal pain, and early satiety.
A contrast enhanced computed tomography (CT) of the abdomen and pelvis revealed splenomegaly, and a homogenous, moderately enhancing lesion measuring 8 x 9 cm in the region of the right adrenal gland (Fig.
In this process, we noted an extremely increased incidence of NAFLD compared to that reported in other published autopsy studies, as well as the presence of splenomegaly occurring in a subset of patients with NASH not having advanced hepatic fibrosis.
Four groups of mice (n = 10) were investigated for assessment of pathology including body weight, physiological activities, hepatomegaly and splenomegaly to assess the toxicity of the extracts.
Tropical infections such as visceral leishmania may cause pancytopenia, splenomegaly and a polyclonal rise in immunoglobulins (2).
Splenic rupture following administration of thrombolytic agents has been reported in the presence of myeloproliferative disorders, such as polycythemia vera (7) and in those with splenomegaly secondary to infection (8).
One memorable case involved a young man with portal hypertension and splenomegaly resulting from schistosomiasis.