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sterol regulatory element binding protein
(redirected from Srebp)

   Also found in: Acronyms, Wikipedia 0.01 sec.
sterol regulatory element binding protein [¦ste‚rȯl ¦reg·yə·lə‚tȯr·ē ‚el·ə·mənt ′bīnd·iŋ ‚prō‚tēn]
(biochemistry)
A transcription factor required for the active transcription of genes that encode the low-density lipoprotein receptor and enzymes in cholesterol synthesis.


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SREBP (sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine mono-phosphate kinase) that turns SREBP on and off.
The researchers focused on two key regulators of lipid (fat) metabolism that are found in many human cells as well: SREBP (sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine monophosphate kinase) that turns SREBP on and off.
1038/nature06179), Alnylam scientists and collaborators demonstrated the ability of synthetic siRNAs to silence three distinct hepatocyte-expressed genes -- apolipoprotein B, factor VII, and SREBP cleavage-activating protein, or "SCAP" -- to levels of greater than 80 percent with both single dose and repeat dose administration of target-specific siRNAs in mice or hamsters.
 
 
 
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