Staphylococcus (redirected from Staphlococci)

staphylococcus (stăf'ələkŏk`əs), any of the pathogenic bacteria, parasitic to humans, that belong to the genus Staphylococcus. The spherical bacterial cells (cocci) typically occur in irregular clusters [Gr. staphyle=bunch of grapes]. The term staphylococcus is also sometimes used loosely for the cluster arrangement itself and, broadly, for any bacteria with such a growth pattern. The pigments produced by staphylococci are the basis of the names given to the various strains—those with colors ranging from orange to yellow are designated S. aureus; white strains are known as S. albus.

Staphylococci cause abscesses, boils, and other infections of the skin, such as impetigo. They can also produce infection in any organ of the body (e.g., staphylococcal pneumonia of the lungs). The most common form of food poisoning is brought on by staphylococcus-contaminated food. The staphylococcus organisms also generate toxins and enzymes that can destroy both red and white blood cells.

Unlike some other types of bacteria, staphylococci are generally partly or wholly resistant to antibiotic action; this raises serious problems in the treatment and control of staphylococcus infections (see drug resistance). The rise of drug-resistant virulent strains of S. aureus has led increasing concern in the medical community. Although sick patients with compromised immune systems and children are most susceptible to the strains, healthy persons have also been infected. Pharmaceutical companies are working to develop new antibiotics to kill drug-resistant strains of staphylococcus and other bacteria, and a vaccine for S. aureus has been developed.

---

staphylococcus

Any of the spherical bacteria that make up the genus Staphylococcus. The best-known species are present in great numbers on the mucous membranes and skin of all humans and other warm-blooded animals. The cells characteristically group together in grapelike clusters. Staphylococci are gram-positive (see gram stain) and stationary and do not require oxygen. Of significance to humans is the species S. aureus, an important agent of wound infections, boils, and other human skin infections, and one of the most common causes of food poisoning. It also causes udder inflammation in domestic animals and breast infections in women. The largest cause of hospital infections (accounting for almost 15%), “staph” is often difficult to treat because of its increasing resistance to antibiotics.

---

Staphylococcus

A genus of bacteria containing at least 28 species that are collectively referred to as staphylococci. Their usual habitat is animal skin and mucosal surfaces. Although the genus is known for the ability of some species to cause infectious diseases, many species rarely cause infections. Pathogenic staphylococci are usually opportunists and cause illness only in compromised hosts. Staphylococcus aureus, the most pathogenic species, is usually identified by its ability to produce coagulase (proteins that affect fibrinogen of the blood-clotting cascade). Since most other species of staphylococci do not produce coagulase, it is useful to divide staphylococci into coagulase-positive and coagulase-negative species. Coagulase-negative staphylococci are not highly virulent but are an important cause of infections in certain high-risk groups. Although Staphylococcus infections were once readily treatable with antibiotics, some strains have acquired genes making them resistant to multiple antimicrobial agents. See Bacteria, Drug resistance, Medical bacteriology

Staphylococcus cells are spherical with a diameter of 0.5–1.5 micrometers. Clumps of staphylococci resemble bunches of grapes when viewed with a microscope, owing to cell division in multiple planes. The staphylococci have a gram-positive cell composition, with a unique peptidoglycan structure that is highly cross-linked with bridges of amino acids. See Stain (microbiology)

Most species are facultative anaerobes. Within a single species, there is a high degree of strain variation in nutritional requirements. Staphylococci are quite resistant to desiccation and high-osmotic conditions. These properties facilitate their survival in the environment, growth in food, and communicability.

In addition to genetic information on the chromosome, pathogenic staphylococci often contain accessory elements such as plasmids, bacteriophages, pathogenicity islands (DNA clusters containing genes associated with pathogenesis), and transposons. These elements harbor genes that encode toxins or resistance to antimicrobial agents and may be transferred to other strains. Genes involved in virulence, especially those coding for exotoxins and surface-binding proteins, are coordinately or simultaneously regulated by loci on the chromosome. See Bacterial genetics, Bacteriophage, Plasmid, Transposons

Most Staphylococcus aureus infections develop into a pyogenic (pus-forming) lesion caused by acute inflammation. Inflammation helps eliminate the bacteria but also damages tissue at the site of infection. Typical pyogenic lesions are abscesses with purulent centers containing leukocytes, fluid, and bacteria. Pyogenic infections can occur anywhere in the body. Blood infections (septicemia) can disseminate the organism throughout the body and abscesses can form internally.

Certain strains of S. aureus produce exotoxins that mediate two illnesses, toxic shock syndrome and staphylococcal scalded skin syndrome. In both diseases, exotoxins are produced during an infection, diffuse from the site of infection, and are carried by the blood (toxemia) to other sites of the body, causing symptoms to develop at sites distant from the infection. Toxic shock syndrome is an acute life-threatening illness mediated by staphylococcal superantigen exotoxins. Staphylococcal scalded skin syndrome, also known as Ritter's disease, refers to several staphylococcal toxigenic infections. It is characterized by dermatologic abnormalities caused by two related exotoxins, the type A and B exfoliative (epidermolytic) toxins. See Cellular immunology, Toxic shock syndrome

Staphylococcal food poisoning is not an infection, but an intoxication that results from ingestion of staphylococcal enterotoxins in food. The enterotoxins are produced when food contaminated with S. aureus is improperly stored under conditions that allow the bacteria to grow. Although contamination can originate from animals or the environment, food preparers with poor hygiene are the usual source. Effective methods for preventing staphylococcal food poisoning are aimed at eliminating contamination through common hygiene practices, such as wearing gloves, and proper food storage to minimize toxin production. See Food poisoning

Coagulase-positive staphylococci are the most important Staphylococcus pathogens for animals. Certain diseases of pets and farm animals are very prominent. Staphylococcus aureus is the leading cause of infectious mastitis in dairy animals.