asymmetric synthesis (redirected from Stereoselective synthesis)

asymmetric synthesis

Chemical reaction by which unequal amounts of two product isomers are formed. It is normally not possible to synthesize from materials that do not have optical activity (i.e., are not chiral) one stereoisomer of a chiral compound without the other, but use of a chiral auxiliary, such as an enzyme or other catalyst, a solvent, or an intermediate, can force the reaction to produce predominantly or only one isomer. Asymmetric syntheses are often called stereoselective; if one product forms exclusively, it is stereospecific.

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asymmetric synthesis [¦ā·sə¦me·trik ′sin·thə·səs]

(organic chemistry)

Chemical synthesis of a pure enantiomer, or of an enantiomorphic mixture in which one enantiomer predominates, without the use of resolution.